| http://purl.uniprot.org/citations/12116189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12116189 | http://www.w3.org/2000/01/rdf-schema#comment | "Cholinergic neurons have been implicated in depression and in the disorders of REM sleep in depression. We examined a common A-> T 1890 polymorphism in the 3' UTR of the cholinergic muscarinic receptor 2 (CHRM2) gene. There was a significant increase in the frequency of 11 homozygotes in 126 women with major depression (43.7%) compared to 304 women without major depression (25.7%), P =.001. There was no increase in the frequency of 11 homozygotes in 52 men with depression (26.9%) compared to 278 men without depression (27.7%). Regression analysis, scoring subjects with the 11 genotype as 1, and those with other genotypes as 0, showed that in women r(2) =.030, F = 13.37, P =.0003. By contrast, in men r(2) =.00001, F = 0.002, P =.96. These results are consistent with a gender-specific role of the CHRM2 gene in depression in women."xsd:string |
| http://purl.uniprot.org/citations/12116189 | http://purl.org/dc/terms/identifier | "doi:10.1002/ajmg.10406"xsd:string |
| http://purl.uniprot.org/citations/12116189 | http://purl.uniprot.org/core/author | "Wu S."xsd:string |
| http://purl.uniprot.org/citations/12116189 | http://purl.uniprot.org/core/author | "Rostamkhani M."xsd:string |
| http://purl.uniprot.org/citations/12116189 | http://purl.uniprot.org/core/author | "Comings D.E."xsd:string |
| http://purl.uniprot.org/citations/12116189 | http://purl.uniprot.org/core/author | "MacMurray J.P."xsd:string |
| http://purl.uniprot.org/citations/12116189 | http://purl.uniprot.org/core/author | "McGue M."xsd:string |
| http://purl.uniprot.org/citations/12116189 | http://purl.uniprot.org/core/author | "Iacono W.G."xsd:string |
| http://purl.uniprot.org/citations/12116189 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12116189 | http://purl.uniprot.org/core/name | "Am J Med Genet"xsd:string |
| http://purl.uniprot.org/citations/12116189 | http://purl.uniprot.org/core/pages | "527-529"xsd:string |
| http://purl.uniprot.org/citations/12116189 | http://purl.uniprot.org/core/title | "Association of the muscarinic cholinergic 2 receptor (CHRM2) gene with major depression in women."xsd:string |
| http://purl.uniprot.org/citations/12116189 | http://purl.uniprot.org/core/volume | "114"xsd:string |
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