| http://purl.uniprot.org/citations/12119102 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12119102 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12119102 | http://www.w3.org/2000/01/rdf-schema#comment | "Glutamate is an important amino acid implicated in energy metabolism, protein biosynthesis and neurotransmission. The Na(+)-dependent high-affinity excitatory amino acid transporter EAAT3 (EAAC1) facilitates glutamate uptake into most cells. Recently, a novel rat EAAT3-interacting protein called GTRAP3-18 has been identified by a yeast two-hybrid screening. GTRAP3-18 functions as a negative modulator of EAAT3-mediated glutamate transport. In order to further understand the function and regulation of GTRAP3-18, we cloned the mouse orthologue to GTRAP3-18 and determined its gene structure and its expression pattern. GTRAP3-18 encodes a 188-residue hydrophobic protein whose sequence is highly conserved amongst vertebrates. Mouse and human GTRAP3-18 genes contain three exons separated by two introns. The GTRAP3-18 gene is found on mouse chromosome 6D3 and on human chromosome 3p14, a susceptibility locus for cancer and epilepsy. GTRAP3-18 protein and RNA were found both in neuronal rich regions of the brain and in non-neuronal tissues such as the kidney, heart and skeletal muscle. Mouse GTRAP3-18 inhibited EAAT3-mediated glutamate transport in a dose-dependent manner. These studies show that GTRAP3-18 is a ubiquitously expressed protein that functions as a negative regulator of EAAT3 function."xsd:string |
| http://purl.uniprot.org/citations/12119102 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0378-1119(02)00669-8"xsd:string |
| http://purl.uniprot.org/citations/12119102 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0378-1119(02)00669-8"xsd:string |
| http://purl.uniprot.org/citations/12119102 | http://purl.uniprot.org/core/author | "Lai L."xsd:string |
| http://purl.uniprot.org/citations/12119102 | http://purl.uniprot.org/core/author | "Lai L."xsd:string |
| http://purl.uniprot.org/citations/12119102 | http://purl.uniprot.org/core/author | "Lin C.-L.G."xsd:string |
| http://purl.uniprot.org/citations/12119102 | http://purl.uniprot.org/core/author | "Lin C.-L.G."xsd:string |
| http://purl.uniprot.org/citations/12119102 | http://purl.uniprot.org/core/author | "Butchbach M.E.R."xsd:string |
| http://purl.uniprot.org/citations/12119102 | http://purl.uniprot.org/core/author | "Butchbach M.E.R."xsd:string |
| http://purl.uniprot.org/citations/12119102 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12119102 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12119102 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/12119102 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/12119102 | http://purl.uniprot.org/core/pages | "81-90"xsd:string |
| http://purl.uniprot.org/citations/12119102 | http://purl.uniprot.org/core/pages | "81-90"xsd:string |
| http://purl.uniprot.org/citations/12119102 | http://purl.uniprot.org/core/title | "Molecular cloning, gene structure, expression profile and functional characterization of the mouse glutamate transporter (EAAT3) interacting protein GTRAP3-18."xsd:string |
| http://purl.uniprot.org/citations/12119102 | http://purl.uniprot.org/core/title | "Molecular cloning, gene structure, expression profile and functional characterization of the mouse glutamate transporter (EAAT3) interacting protein GTRAP3-18."xsd:string |
| http://purl.uniprot.org/citations/12119102 | http://purl.uniprot.org/core/volume | "292"xsd:string |
| http://purl.uniprot.org/citations/12119102 | http://purl.uniprot.org/core/volume | "292"xsd:string |
| http://purl.uniprot.org/citations/12119102 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12119102 |
| http://purl.uniprot.org/citations/12119102 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12119102 |
| http://purl.uniprot.org/citations/12119102 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12119102 |
| http://purl.uniprot.org/citations/12119102 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12119102 |