| http://purl.uniprot.org/citations/12121673 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12121673 | http://www.w3.org/2000/01/rdf-schema#comment | "Human leukocyte antigen A (HLA-A) genotypes were determined for samples from 283 multiplex, Caucasian, type 1 diabetes families from the Human Biological Data Interchange (HBDI) using an immobilized probe assay. Distribution of HLA-A alleles transmitted to patients was significantly different from that in affected family-based controls (AFBAC) (p = 0.004). Transmission disequilibrium test (TDT) analysis revealed differential transmission of several HLA-A alleles from parents to affected offspring. HLA class II DRB1 and DQB1 loci were also typed, allowing assignment of HLA-A alleles to haplotypes and calculation of linkage disequilibrium values. Some of the apparent effects of HLA-A alleles on type 1 diabetes susceptibility were attributable to linkage disequilibrium with DR and DQ alleles, although others were not. The differences in frequencies between patients and controls of alleles A*0101, A*2402, and A*3002 could not be explained by linkage disequilibrium alone. Our results suggest an important role for class I antigens in modulating susceptibility to type 1 diabetes."xsd:string |
| http://purl.uniprot.org/citations/12121673 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0198-8859(02)00421-4"xsd:string |
| http://purl.uniprot.org/citations/12121673 | http://purl.uniprot.org/core/author | "Noble J.A."xsd:string |
| http://purl.uniprot.org/citations/12121673 | http://purl.uniprot.org/core/author | "Thomson G."xsd:string |
| http://purl.uniprot.org/citations/12121673 | http://purl.uniprot.org/core/author | "Bugawan T.L."xsd:string |
| http://purl.uniprot.org/citations/12121673 | http://purl.uniprot.org/core/author | "Erlich H.A."xsd:string |
| http://purl.uniprot.org/citations/12121673 | http://purl.uniprot.org/core/author | "Apple R.J."xsd:string |
| http://purl.uniprot.org/citations/12121673 | http://purl.uniprot.org/core/author | "Valdes A.M."xsd:string |
| http://purl.uniprot.org/citations/12121673 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12121673 | http://purl.uniprot.org/core/name | "Hum Immunol"xsd:string |
| http://purl.uniprot.org/citations/12121673 | http://purl.uniprot.org/core/pages | "657-664"xsd:string |
| http://purl.uniprot.org/citations/12121673 | http://purl.uniprot.org/core/title | "The HLA class I A locus affects susceptibility to type 1 diabetes."xsd:string |
| http://purl.uniprot.org/citations/12121673 | http://purl.uniprot.org/core/volume | "63"xsd:string |
| http://purl.uniprot.org/citations/12121673 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12121673 |
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