| http://purl.uniprot.org/citations/12122006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12122006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12122006 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclin F, a cyclin that can form SCF complexes and bind to cyclin B, oscillates in the cell cycle with a pattern similar to cyclin A and cyclin B. Ectopic expression of cyclin F arrests the cell cycle in G(2)/M. How the level of cyclin F is regulated during the cell cycle is completely obscure. Here we show that, similar to cyclin A, cyclin F is degraded when the spindle assembly checkpoint is activated and accumulates when the DNA damage checkpoint is activated. Cyclin F is a very unstable protein throughout much of the cell cycle. Unlike other cyclins, degradation of cyclin F is independent of ubiquitination and proteasome-mediated pathways. Interestingly, proteolysis of cyclin F is likely to involve metalloproteases. Rapid destruction of cyclin F does not require the N-terminal F-box motif but requires the COOH-terminal PEST sequences. The PEST region alone is sufficient to interfere with the degradation of cyclin F and confer instability when fused to cyclin A. These data show that although cyclin F is degraded at similar time as the mitotic cyclins, the underlying mechanisms are entirely distinct."xsd:string |
| http://purl.uniprot.org/citations/12122006 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m205503200"xsd:string |
| http://purl.uniprot.org/citations/12122006 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m205503200"xsd:string |
| http://purl.uniprot.org/citations/12122006 | http://purl.uniprot.org/core/author | "Fung T.K."xsd:string |
| http://purl.uniprot.org/citations/12122006 | http://purl.uniprot.org/core/author | "Fung T.K."xsd:string |
| http://purl.uniprot.org/citations/12122006 | http://purl.uniprot.org/core/author | "Lau A."xsd:string |
| http://purl.uniprot.org/citations/12122006 | http://purl.uniprot.org/core/author | "Lau A."xsd:string |
| http://purl.uniprot.org/citations/12122006 | http://purl.uniprot.org/core/author | "Poon R.Y."xsd:string |
| http://purl.uniprot.org/citations/12122006 | http://purl.uniprot.org/core/author | "Poon R.Y."xsd:string |
| http://purl.uniprot.org/citations/12122006 | http://purl.uniprot.org/core/author | "Siu W.Y."xsd:string |
| http://purl.uniprot.org/citations/12122006 | http://purl.uniprot.org/core/author | "Siu W.Y."xsd:string |
| http://purl.uniprot.org/citations/12122006 | http://purl.uniprot.org/core/author | "Yam C.H."xsd:string |
| http://purl.uniprot.org/citations/12122006 | http://purl.uniprot.org/core/author | "Yam C.H."xsd:string |
| http://purl.uniprot.org/citations/12122006 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12122006 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12122006 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12122006 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12122006 | http://purl.uniprot.org/core/pages | "35140-35149"xsd:string |
| http://purl.uniprot.org/citations/12122006 | http://purl.uniprot.org/core/pages | "35140-35149"xsd:string |
| http://purl.uniprot.org/citations/12122006 | http://purl.uniprot.org/core/title | "Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins."xsd:string |
| http://purl.uniprot.org/citations/12122006 | http://purl.uniprot.org/core/title | "Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins."xsd:string |
| http://purl.uniprot.org/citations/12122006 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/12122006 | http://purl.uniprot.org/core/volume | "277"xsd:string |