| http://purl.uniprot.org/citations/12122109 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12122109 | http://www.w3.org/2000/01/rdf-schema#comment | "The Polycomb-group (PcG) gene Rae28 is a mammalian homologue of the Drosophila gene polyhomeotic. PcG genes are known to maintain transcription states, once initiated, probably by regulating chromatin structure. Since homozygous Rae28-deficient (Rae28(-/-)) mice displayed cardiac anomalies similar to congenital heart diseases in humans, we examined the role of Rae28 in cardiac morphogenesis at the molecular level. In Rae28(-/-) embryos, expression of the cardiac selector gene Nkx2.5/Csx (Nkx2.5) was initiated properly but was not sufficiently sustained later in development. This impaired expression of Nkx2.5 in the maintenance phase proved to have a crucial effect on cardiac morphogenesis, as demonstrated by the results of a genetic complementation experiment in which the cardiac anomalies were suppressed by overexpression of human NKX2.5/CSX1 in Rae28(-/-) embryos. Ubiquitous expression of exogenous Rae28 likewise restored the impaired Nkx2.5 expression in Rae28(-/-) embryos, further supporting the notion that Rae28 sustains Nkx2.5 expression in cardiomyocytes. Thus, our data show that a mammalian PcG gene can play a key role in organogenesis by helping to maintain the expression of a selector gene."xsd:string |
| http://purl.uniprot.org/citations/12122109 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci14839"xsd:string |
| http://purl.uniprot.org/citations/12122109 | http://purl.uniprot.org/core/author | "Koga H."xsd:string |
| http://purl.uniprot.org/citations/12122109 | http://purl.uniprot.org/core/author | "Takihara Y."xsd:string |
| http://purl.uniprot.org/citations/12122109 | http://purl.uniprot.org/core/author | "Shirai M."xsd:string |
| http://purl.uniprot.org/citations/12122109 | http://purl.uniprot.org/core/author | "Miwa T."xsd:string |
| http://purl.uniprot.org/citations/12122109 | http://purl.uniprot.org/core/author | "Komuro I."xsd:string |
| http://purl.uniprot.org/citations/12122109 | http://purl.uniprot.org/core/author | "Takimoto E."xsd:string |
| http://purl.uniprot.org/citations/12122109 | http://purl.uniprot.org/core/author | "Kaji Y."xsd:string |
| http://purl.uniprot.org/citations/12122109 | http://purl.uniprot.org/core/author | "Hara J."xsd:string |
| http://purl.uniprot.org/citations/12122109 | http://purl.uniprot.org/core/author | "Yamauchi-Takihara K."xsd:string |
| http://purl.uniprot.org/citations/12122109 | http://purl.uniprot.org/core/author | "Osugi T."xsd:string |
| http://purl.uniprot.org/citations/12122109 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12122109 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/12122109 | http://purl.uniprot.org/core/pages | "177-184"xsd:string |
| http://purl.uniprot.org/citations/12122109 | http://purl.uniprot.org/core/title | "The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis."xsd:string |
| http://purl.uniprot.org/citations/12122109 | http://purl.uniprot.org/core/volume | "110"xsd:string |
| http://purl.uniprot.org/citations/12122109 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12122109 |
| http://purl.uniprot.org/citations/12122109 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12122109 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JE15-mappedCitation-12122109 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12122109 |
| http://purl.uniprot.org/uniprot/#_D3YW14-mappedCitation-12122109 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12122109 |
| http://purl.uniprot.org/uniprot/#_D3Z0I3-mappedCitation-12122109 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12122109 |
| http://purl.uniprot.org/uniprot/#_E0CXT0-mappedCitation-12122109 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12122109 |
| http://purl.uniprot.org/uniprot/#_E0CXV8-mappedCitation-12122109 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12122109 |