| http://purl.uniprot.org/citations/12122115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12122115 | http://www.w3.org/2000/01/rdf-schema#comment | "Inappropriate activation of the renin-angiotensin system, which plays a central role in the regulation of blood pressure, electrolyte, and volume homeostasis, may represent a major risk factor for hypertension, heart attack, and stroke. Mounting evidence from clinical studies has demonstrated an inverse relationship between circulating vitamin D levels and the blood pressure and/or plasma renin activity, but the mechanism is not understood. We show here that renin expression and plasma angiotensin II production were increased severalfold in vitamin D receptor-null (VDR-null) mice, leading to hypertension, cardiac hypertrophy, and increased water intake. However, the salt- and volume-sensing mechanisms that control renin synthesis are still intact in the mutant mice. In wild-type mice, inhibition of 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] synthesis also led to an increase in renin expression, whereas 1,25(OH)(2)D(3) injection led to renin suppression. We found that vitamin D regulation of renin expression was independent of calcium metabolism and that 1,25(OH)(2)D(3) markedly suppressed renin transcription by a VDR-mediated mechanism in cell cultures. Hence, 1,25(OH)(2)D(3) is a novel negative endocrine regulator of the renin-angiotensin system. Its apparent critical role in electrolytes, volume, and blood pressure homeostasis suggests that vitamin D analogues could help prevent or ameliorate hypertension."xsd:string |
| http://purl.uniprot.org/citations/12122115 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci15219"xsd:string |
| http://purl.uniprot.org/citations/12122115 | http://purl.uniprot.org/core/author | "Kong J."xsd:string |
| http://purl.uniprot.org/citations/12122115 | http://purl.uniprot.org/core/author | "Wei M."xsd:string |
| http://purl.uniprot.org/citations/12122115 | http://purl.uniprot.org/core/author | "Chen Z.F."xsd:string |
| http://purl.uniprot.org/citations/12122115 | http://purl.uniprot.org/core/author | "Li Y.C."xsd:string |
| http://purl.uniprot.org/citations/12122115 | http://purl.uniprot.org/core/author | "Liu S.Q."xsd:string |
| http://purl.uniprot.org/citations/12122115 | http://purl.uniprot.org/core/author | "Cao L.P."xsd:string |
| http://purl.uniprot.org/citations/12122115 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12122115 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/12122115 | http://purl.uniprot.org/core/pages | "229-238"xsd:string |
| http://purl.uniprot.org/citations/12122115 | http://purl.uniprot.org/core/title | "1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system."xsd:string |
| http://purl.uniprot.org/citations/12122115 | http://purl.uniprot.org/core/volume | "110"xsd:string |
| http://purl.uniprot.org/citations/12122115 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12122115 |
| http://purl.uniprot.org/citations/12122115 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12122115 |
| http://purl.uniprot.org/uniprot/#_A0A286YD23-mappedCitation-12122115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12122115 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J021-mappedCitation-12122115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12122115 |
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| http://purl.uniprot.org/uniprot/#_G3UWM9-mappedCitation-12122115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12122115 |
| http://purl.uniprot.org/uniprot/#_G3UZP9-mappedCitation-12122115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12122115 |
| http://purl.uniprot.org/uniprot/#_G3UXG5-mappedCitation-12122115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12122115 |
| http://purl.uniprot.org/uniprot/#_O09102-mappedCitation-12122115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12122115 |
| http://purl.uniprot.org/uniprot/#_P48281-mappedCitation-12122115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12122115 |
| http://purl.uniprot.org/uniprot/#_Q4FJV8-mappedCitation-12122115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12122115 |