http://purl.uniprot.org/citations/12123607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/12123607 | http://www.w3.org/2000/01/rdf-schema#comment | "Here we present the identification and characterization of dHb9, the Drosophila homolog of vertebrate Hb9, which encodes a factor central to motorneuron (MN) development. We show that dHb9 regulates neuronal fate by restricting expression of Lim3 and Even-skipped (Eve), two homeodomain (HD) proteins required for development of distinct neuronal classes. Also, dHb9 and Lim3 are activated independently of each other in a virtually identical population of ventrally and laterally projecting MNs. Surprisingly, dHb9 represses Lim3 cell nonautonomously in a subset of dorsally projecting MNs, revealing a novel role for intercellular signaling in the establishment of neuronal fate in Drosophila. Lastly, we provide evidence that dHb9 and Eve regulate each other's expression through Groucho-dependent crossrepression. This mutually antagonistic relationship bears similarity to the crossrepressive relationships between pairs of HD proteins that pattern the vertebrate neural tube."xsd:string |
http://purl.uniprot.org/citations/12123607 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(02)00743-2"xsd:string |
http://purl.uniprot.org/citations/12123607 | http://purl.uniprot.org/core/author | "Skeath J.B."xsd:string |
http://purl.uniprot.org/citations/12123607 | http://purl.uniprot.org/core/author | "Broihier H.T."xsd:string |
http://purl.uniprot.org/citations/12123607 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
http://purl.uniprot.org/citations/12123607 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
http://purl.uniprot.org/citations/12123607 | http://purl.uniprot.org/core/pages | "39-50"xsd:string |
http://purl.uniprot.org/citations/12123607 | http://purl.uniprot.org/core/title | "Drosophila homeodomain protein dHb9 directs neuronal fate via crossrepressive and cell-nonautonomous mechanisms."xsd:string |
http://purl.uniprot.org/citations/12123607 | http://purl.uniprot.org/core/volume | "35"xsd:string |
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