| http://purl.uniprot.org/citations/12133006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12133006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12133006 | http://www.w3.org/2000/01/rdf-schema#comment | "Nr-13 is an anti-apoptotic member of the Bcl-2 family previously shown to interact with Bax. The biological significance of this interaction was explored both in yeast and vertebrate cells and revealed that Nr-13 is able to counteract the pro-apoptotic activity of Bax. The Bax-interacting domain has been identified and corresponds to alpha-helices 5 and 6 in Nr-13. Site-directed mutagenesis has revealed that the N-terminal region of Nr-13 is essential for activity and corresponds to a genuine Bcl-2 homology domain (BH4). The modelling of Nr-13, based on its similarity with other Bcl-2 family proteins and energy minimization, suggests the possibility of electrostatic interactions between the two N-terminal-conserved domains BH4 and BH3. Disruption of these interactions severely affects Nr-13 anti-apoptotic activity. Together our results suggest that electrostatic interactions between BH4 and BH3 domains play a role in the control of activity of Nr-13 and a subset of Bcl-2 family members."xsd:string |
| http://purl.uniprot.org/citations/12133006 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20020836"xsd:string |
| http://purl.uniprot.org/citations/12133006 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20020836"xsd:string |
| http://purl.uniprot.org/citations/12133006 | http://purl.uniprot.org/core/author | "Geourjon C."xsd:string |
| http://purl.uniprot.org/citations/12133006 | http://purl.uniprot.org/core/author | "Geourjon C."xsd:string |
| http://purl.uniprot.org/citations/12133006 | http://purl.uniprot.org/core/author | "Deleage G."xsd:string |
| http://purl.uniprot.org/citations/12133006 | http://purl.uniprot.org/core/author | "Deleage G."xsd:string |
| http://purl.uniprot.org/citations/12133006 | http://purl.uniprot.org/core/author | "Aouacheria A."xsd:string |
| http://purl.uniprot.org/citations/12133006 | http://purl.uniprot.org/core/author | "Aouacheria A."xsd:string |
| http://purl.uniprot.org/citations/12133006 | http://purl.uniprot.org/core/author | "Gillet G."xsd:string |
| http://purl.uniprot.org/citations/12133006 | http://purl.uniprot.org/core/author | "Gillet G."xsd:string |
| http://purl.uniprot.org/citations/12133006 | http://purl.uniprot.org/core/author | "Lalle P."xsd:string |
| http://purl.uniprot.org/citations/12133006 | http://purl.uniprot.org/core/author | "Lalle P."xsd:string |
| http://purl.uniprot.org/citations/12133006 | http://purl.uniprot.org/core/author | "Venet S."xsd:string |
| http://purl.uniprot.org/citations/12133006 | http://purl.uniprot.org/core/author | "Venet S."xsd:string |
| http://purl.uniprot.org/citations/12133006 | http://purl.uniprot.org/core/author | "Colas P."xsd:string |
| http://purl.uniprot.org/citations/12133006 | http://purl.uniprot.org/core/author | "Colas P."xsd:string |
| http://purl.uniprot.org/citations/12133006 | http://purl.uniprot.org/core/author | "Bobichon H."xsd:string |
| http://purl.uniprot.org/citations/12133006 | http://purl.uniprot.org/core/author | "Bobichon H."xsd:string |
| http://purl.uniprot.org/citations/12133006 | http://purl.uniprot.org/core/author | "Dumont-Miscopein A."xsd:string |
| http://purl.uniprot.org/citations/12133006 | http://purl.uniprot.org/core/author | "Dumont-Miscopein A."xsd:string |
| http://purl.uniprot.org/citations/12133006 | http://purl.uniprot.org/core/author | "Jambon M."xsd:string |
| http://purl.uniprot.org/citations/12133006 | http://purl.uniprot.org/core/author | "Jambon M."xsd:string |