| http://purl.uniprot.org/citations/12138009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12138009 | http://www.w3.org/2000/01/rdf-schema#comment | "The purpose of this study was to examine the gastrin-releasing peptide (GRP) mediated regulation of 5-HT neuronal activity in the paraventricular nucleus of the hypothalamus under basal and restraint stress conditions. Intracerebroventricular (icv) administration of GRP (1, 10, 100 ng/rat) increased 5-HIAA concentrations in the paraventricular nucleus (PVN) of the hypothalamus, but was without effect in the accumbens, suprachiasmatic and arcuate nuclei. Administration of (Leu(13)-psi-CH(2)NH-Leu(14)) Bombesin (10, 100 and 1000 ng/rat; icv), a GRP antagonist, had no effect by itself on PVN serotonergic activity; however, a dose of 1 microg/rat of this compound, completely blocked the increase of 5-HIAA concentrations induced by GRP (10 ng). Restraint stress increased serotonergic activity -as shown by an elevation of 5-HIAA in the PVN-as well as plasma ACTH and corticosterone. This stress-induced activation of both the serotonergic neurons and the hypothalamus-pituitary-adrenal axis was blocked by CRF and GRP antagonists. Interestingly, when the activation of hypothalamic 5-HT neurons was induced by GRP administration, alpha-helical (9-41) CRF was ineffective. These data suggest that GRP, by acting on GRP receptors but not via CRF receptors, increases 5-HT neuronal activity in the PVN. In turn, it appears that endogenous GRP and CRF receptor ligands are both simultaneously involved in the regulation of the increase in 5-HT neuronal activity, ACTH and corticosterone secretion, under stress conditions."xsd:string |
| http://purl.uniprot.org/citations/12138009 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0024-3205(02)01558-8"xsd:string |
| http://purl.uniprot.org/citations/12138009 | http://purl.uniprot.org/core/author | "Fuentes J.A."xsd:string |
| http://purl.uniprot.org/citations/12138009 | http://purl.uniprot.org/core/author | "Manzanares J."xsd:string |
| http://purl.uniprot.org/citations/12138009 | http://purl.uniprot.org/core/author | "Garrido M.M."xsd:string |
| http://purl.uniprot.org/citations/12138009 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12138009 | http://purl.uniprot.org/core/name | "Life Sci"xsd:string |
| http://purl.uniprot.org/citations/12138009 | http://purl.uniprot.org/core/pages | "2953-2966"xsd:string |
| http://purl.uniprot.org/citations/12138009 | http://purl.uniprot.org/core/title | "Gastrin-releasing peptide mediated regulation of 5-HT neuronal activity in the hypothalamic paraventricular nucleus under basal and restraint stress conditions."xsd:string |
| http://purl.uniprot.org/citations/12138009 | http://purl.uniprot.org/core/volume | "70"xsd:string |
| http://purl.uniprot.org/citations/12138009 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12138009 |
| http://purl.uniprot.org/citations/12138009 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12138009 |
| http://purl.uniprot.org/uniprot/#_P24393-mappedCitation-12138009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12138009 |
| http://purl.uniprot.org/uniprot/P24393 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12138009 |