| http://purl.uniprot.org/citations/12138115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12138115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12138115 | http://www.w3.org/2000/01/rdf-schema#comment | "Frizzled has been known to function as a Wnt receptor. Although there have been a number of mammalian Frizzled members identified, their binding specificities with Wnt and functions in mammalian cells have been poorly understood. Here, we demonstrate that rat Frizzled-9 (Rfz9) functions in Wnt/beta-catenin signaling in 293T cells. Rfz9 overexpression induces the hyperphosphorylation and relocalization of mouse Dishevelled-1 (Dvl-1) from the cytoplasm to the cell membrane and the accumulation of cytosolic beta-catenin. Transfections of Rfz9 with each of several Wnt members show that only Wnt-2 activates Rfz9 in T cell factor (TCF)-dependent transcription. Deletion mutant analysis determines that there is a difference in Rfz9 C-terminal residues required for the modifications of Dvl-1 and those required for the inductions of beta-catenin stabilization and TCF transactivation. Deletion of the Wnt-binding domain does not abolish Rfz9 activity completely, although it causes the inactivation of Wnt-2-dependent TCF transcription. Rfz9 also relocalizes Axin from the cytoplasm to the plasma membrane in the presence of Dvl-1, suggesting that one of the consequences of Dvl-1 relocalization by Rfz9 is to bring Axin to the cell membrane."xsd:string |
| http://purl.uniprot.org/citations/12138115 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m205658200"xsd:string |
| http://purl.uniprot.org/citations/12138115 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m205658200"xsd:string |
| http://purl.uniprot.org/citations/12138115 | http://purl.uniprot.org/core/author | "Karasawa T."xsd:string |
| http://purl.uniprot.org/citations/12138115 | http://purl.uniprot.org/core/author | "Karasawa T."xsd:string |
| http://purl.uniprot.org/citations/12138115 | http://purl.uniprot.org/core/author | "Kitajewski J."xsd:string |
| http://purl.uniprot.org/citations/12138115 | http://purl.uniprot.org/core/author | "Kitajewski J."xsd:string |
| http://purl.uniprot.org/citations/12138115 | http://purl.uniprot.org/core/author | "Lombroso P.J."xsd:string |
| http://purl.uniprot.org/citations/12138115 | http://purl.uniprot.org/core/author | "Lombroso P.J."xsd:string |
| http://purl.uniprot.org/citations/12138115 | http://purl.uniprot.org/core/author | "Yokokura H."xsd:string |
| http://purl.uniprot.org/citations/12138115 | http://purl.uniprot.org/core/author | "Yokokura H."xsd:string |
| http://purl.uniprot.org/citations/12138115 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12138115 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12138115 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12138115 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12138115 | http://purl.uniprot.org/core/pages | "37479-37486"xsd:string |
| http://purl.uniprot.org/citations/12138115 | http://purl.uniprot.org/core/pages | "37479-37486"xsd:string |
| http://purl.uniprot.org/citations/12138115 | http://purl.uniprot.org/core/title | "Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling."xsd:string |
| http://purl.uniprot.org/citations/12138115 | http://purl.uniprot.org/core/title | "Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling."xsd:string |
| http://purl.uniprot.org/citations/12138115 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/12138115 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/12138115 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12138115 |
| http://purl.uniprot.org/citations/12138115 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12138115 |