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| http://purl.uniprot.org/citations/12138190 | http://www.w3.org/2000/01/rdf-schema#comment | "A cDNA library enriched with Myc-responsive cDNAs but depleted of myc cDNAs was used in a functional screen for growth enhancement in c-myc-null cells. A cDNA clone for mitochondrial serine hydroxymethyltransferase (mSHMT) that was capable of partial complementation of the growth defects of c-myc-null cells was identified. Expression analysis and chromatin immunoprecipitation demonstrated that mSHMT is a direct Myc target gene. Furthermore, a separate gene encoding the cytoplasmic isoform of the same enzyme is also a direct target of Myc regulation. SHMT enzymes are the major source of the one-carbon unit required for folate metabolism and for the biosynthesis of nucleotides and amino acids. Our data establish a novel functional link between Myc and the regulation of cellular metabolism."xsd:string |
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| http://purl.uniprot.org/citations/12138190 | http://purl.uniprot.org/core/author | "Cole M.D."xsd:string |
| http://purl.uniprot.org/citations/12138190 | http://purl.uniprot.org/core/author | "Beavis A."xsd:string |
| http://purl.uniprot.org/citations/12138190 | http://purl.uniprot.org/core/author | "Petrenko O."xsd:string |
| http://purl.uniprot.org/citations/12138190 | http://purl.uniprot.org/core/author | "Sedivy J.M."xsd:string |
| http://purl.uniprot.org/citations/12138190 | http://purl.uniprot.org/core/author | "O'Connell B."xsd:string |
| http://purl.uniprot.org/citations/12138190 | http://purl.uniprot.org/core/author | "Nikiforov M.A."xsd:string |
| http://purl.uniprot.org/citations/12138190 | http://purl.uniprot.org/core/author | "Chandriani S."xsd:string |
| http://purl.uniprot.org/citations/12138190 | http://purl.uniprot.org/core/author | "Kotenko I."xsd:string |
| http://purl.uniprot.org/citations/12138190 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12138190 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/12138190 | http://purl.uniprot.org/core/pages | "5793-5800"xsd:string |
| http://purl.uniprot.org/citations/12138190 | http://purl.uniprot.org/core/title | "A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism."xsd:string |
| http://purl.uniprot.org/citations/12138190 | http://purl.uniprot.org/core/volume | "22"xsd:string |
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