| http://purl.uniprot.org/citations/12139939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12139939 | http://www.w3.org/2000/01/rdf-schema#comment | "The eukaryotic single-stranded DNA-binding protein, replication protein A (RPA), is essential for DNA replication, and plays important roles in DNA repair and DNA recombination. Rad52 and RPA, along with other members of the Rad52 epistasis group of genes, repair double-stranded DNA breaks (DSBs). Two repair pathways involve RPA and Rad52, homologous recombination and single-strand annealing. Two binding sites for Rad52 have been identified on RPA. They include the previously identified C-terminal domain (CTD) of RPA32 (residues 224-271) and the newly identified domain containing residues 169-326 of RPA70. A region on Rad52, which includes residues 218-303, binds RPA70 as well as RPA32. The N-terminal region of RPA32 does not appear to play a role in the formation of the RPA:Rad52 complex. It appears that the RPA32CTD can substitute for RPA70 in binding Rad52. Sequence homology between RPA32 and RPA70 was used to identify a putative Rad52-binding site on RPA70 that is located near DNA-binding domains A and B. Rad52 binding to RPA increases ssDNA affinity significantly. Mutations in DBD-D on RPA32 show that this domain is primarily responsible for the ssDNA binding enhancement. RPA binding to Rad52 inhibits the higher-order self-association of Rad52 rings. Implications for these results for the "hand-off" mechanism between protein-protein partners, including Rad51, in homologous recombination and single-strand annealing are discussed."xsd:string |
| http://purl.uniprot.org/citations/12139939 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0022-2836(02)00541-7"xsd:string |
| http://purl.uniprot.org/citations/12139939 | http://purl.uniprot.org/core/author | "Jackson D."xsd:string |
| http://purl.uniprot.org/citations/12139939 | http://purl.uniprot.org/core/author | "Wold M.S."xsd:string |
| http://purl.uniprot.org/citations/12139939 | http://purl.uniprot.org/core/author | "Dhar K."xsd:string |
| http://purl.uniprot.org/citations/12139939 | http://purl.uniprot.org/core/author | "Borgstahl G.E."xsd:string |
| http://purl.uniprot.org/citations/12139939 | http://purl.uniprot.org/core/author | "Wahl J.K."xsd:string |
| http://purl.uniprot.org/citations/12139939 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12139939 | http://purl.uniprot.org/core/name | "J Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/12139939 | http://purl.uniprot.org/core/pages | "133-148"xsd:string |
| http://purl.uniprot.org/citations/12139939 | http://purl.uniprot.org/core/title | "Analysis of the human replication protein A:Rad52 complex: evidence for crosstalk between RPA32, RPA70, Rad52 and DNA."xsd:string |
| http://purl.uniprot.org/citations/12139939 | http://purl.uniprot.org/core/volume | "321"xsd:string |
| http://purl.uniprot.org/citations/12139939 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12139939 |
| http://purl.uniprot.org/citations/12139939 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12139939 |
| http://purl.uniprot.org/uniprot/#_P54132-mappedCitation-12139939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12139939 |
| http://purl.uniprot.org/uniprot/#_Q14191-mappedCitation-12139939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12139939 |
| http://purl.uniprot.org/uniprot/#_P49959-mappedCitation-12139939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12139939 |
| http://purl.uniprot.org/uniprot/#_Q13472-mappedCitation-12139939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12139939 |
| http://purl.uniprot.org/uniprot/#_Q13535-mappedCitation-12139939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12139939 |
| http://purl.uniprot.org/uniprot/#_O75943-mappedCitation-12139939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12139939 |
| http://purl.uniprot.org/uniprot/#_P38398-mappedCitation-12139939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12139939 |
| http://purl.uniprot.org/uniprot/#_P15927-mappedCitation-12139939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12139939 |
| http://purl.uniprot.org/uniprot/#_P40937-mappedCitation-12139939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12139939 |
| http://purl.uniprot.org/uniprot/#_P40938-mappedCitation-12139939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12139939 |