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Background

The human leukocyte antigens (HLA) are associated with susceptibility to systemic lupus erythematosus (SLE) and manifestations of SLE in different ethnic groups.

Methods

A DNA-based HLA-typing method was used to determine alleles of HLA-DRB1, DRB3, DRB4 and DRB5 in Jamaican patients. A total of 70 patients and 100 control subjects were studied.

Results

HLA-DRB3*01/03 was significantly associated with susceptibility to SLE, while DRB1*15/16 was associated with the presence of oral ulcers in patients with SLE. The haplotype DRB1*13/14.DRB3*01/03 was also more frequent in SLE patients. No other significant associations were found.

Conclusion

The SLE HLA associations in Jamaicans differ from those in other black populations."xsd:string
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http://purl.uniprot.org/citations/12144077http://purl.uniprot.org/core/author"Dowe G."xsd:string
http://purl.uniprot.org/citations/12144077http://purl.uniprot.org/core/author"Anderson N."xsd:string
http://purl.uniprot.org/citations/12144077http://purl.uniprot.org/core/author"Christian N."xsd:string
http://purl.uniprot.org/citations/12144077http://purl.uniprot.org/core/author"Barton E."xsd:string
http://purl.uniprot.org/citations/12144077http://purl.uniprot.org/core/author"Roye-Green K."xsd:string
http://purl.uniprot.org/citations/12144077http://purl.uniprot.org/core/author"DeCeulaer K."xsd:string
http://purl.uniprot.org/citations/12144077http://purl.uniprot.org/core/author"Smikle M."xsd:string
http://purl.uniprot.org/citations/12144077http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/12144077http://purl.uniprot.org/core/name"South Med J"xsd:string
http://purl.uniprot.org/citations/12144077http://purl.uniprot.org/core/pages"717-719"xsd:string
http://purl.uniprot.org/citations/12144077http://purl.uniprot.org/core/title"HLA-DRB alleles and systemic lupus erythematosus in Jamaicans."xsd:string
http://purl.uniprot.org/citations/12144077http://purl.uniprot.org/core/volume"95"xsd:string
http://purl.uniprot.org/citations/12144077http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12144077
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