| http://purl.uniprot.org/citations/12144530 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12144530 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12144530 | http://www.w3.org/2000/01/rdf-schema#comment | "Small ubiquitin-related modifier-1 (SUMO-1) is covalently attached to many cellular targets to regulate protein-protein and protein-DNA interactions, as well as localization and stability of the target protein. The SUMO-1-conjugating E2 enzyme Ubc9 is known to interact with the glucocorticoid receptor (GR), a ligand-dependent transcription factor. In the present study, we show that GR is post-translationally modified by SUMO-1 (sumoylated) in a ligand-enhanced fashion. We identify experimentally three consensus SUMO attachment sites, two in the N-terminal transactivation region and one in the ligand-binding domain of GR. The two N-terminal sites are the major acceptor sites for SUMO-1 attachment. Mutation of these sites enhances transcriptional activity of GR on minimal promoters, but has no clear effect on the more complex mouse mammary tumour virus promoter. Thus SUMO-1 modification of GR influences receptor function in a promoter context-dependent fashion."xsd:string |
| http://purl.uniprot.org/citations/12144530 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20021085"xsd:string |
| http://purl.uniprot.org/citations/12144530 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20021085"xsd:string |
| http://purl.uniprot.org/citations/12144530 | http://purl.uniprot.org/core/author | "Tian S."xsd:string |
| http://purl.uniprot.org/citations/12144530 | http://purl.uniprot.org/core/author | "Tian S."xsd:string |
| http://purl.uniprot.org/citations/12144530 | http://purl.uniprot.org/core/author | "Palvimo J.J."xsd:string |
| http://purl.uniprot.org/citations/12144530 | http://purl.uniprot.org/core/author | "Palvimo J.J."xsd:string |
| http://purl.uniprot.org/citations/12144530 | http://purl.uniprot.org/core/author | "Jaenne O.A."xsd:string |
| http://purl.uniprot.org/citations/12144530 | http://purl.uniprot.org/core/author | "Jaenne O.A."xsd:string |
| http://purl.uniprot.org/citations/12144530 | http://purl.uniprot.org/core/author | "Poukka H."xsd:string |
| http://purl.uniprot.org/citations/12144530 | http://purl.uniprot.org/core/author | "Poukka H."xsd:string |
| http://purl.uniprot.org/citations/12144530 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12144530 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12144530 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/12144530 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/12144530 | http://purl.uniprot.org/core/pages | "907-911"xsd:string |
| http://purl.uniprot.org/citations/12144530 | http://purl.uniprot.org/core/pages | "907-911"xsd:string |
| http://purl.uniprot.org/citations/12144530 | http://purl.uniprot.org/core/title | "Small ubiquitin-related modifier-1 (SUMO-1) modification of the glucocorticoid receptor."xsd:string |
| http://purl.uniprot.org/citations/12144530 | http://purl.uniprot.org/core/title | "Small ubiquitin-related modifier-1 (SUMO-1) modification of the glucocorticoid receptor."xsd:string |
| http://purl.uniprot.org/citations/12144530 | http://purl.uniprot.org/core/volume | "367"xsd:string |
| http://purl.uniprot.org/citations/12144530 | http://purl.uniprot.org/core/volume | "367"xsd:string |
| http://purl.uniprot.org/citations/12144530 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12144530 |
| http://purl.uniprot.org/citations/12144530 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12144530 |