| http://purl.uniprot.org/citations/12145348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12145348 | http://www.w3.org/2000/01/rdf-schema#comment | "The peptide somatostatin (SST) is widely synthesized in the brain and periphery and acts through a family of five receptors (SSTR1-5) to exert numerous effects. A gene product related to SST, cortistatin (CST), also interacts with SSTR1-5. Here we have investigated the regulation of SSTR1-5 and of CST in SST knockout (SSTKO) mice. The five SSTRs were quantitated individually by subtype-selective binding analysis, by immunocytochemistry, and by mRNA measurement and showed, in the brain of SSTKO mice, up-regulation of subtypes 1, 2, 4, and 5, and down-regulation of SSTR3. Peripheral tissues displayed both subtype- and tissue-specific changes in SSTR1-5 mRNA levels of expression. Lack of SST did not up-regulate normal CST expression in brain nor did it induce its expression in the periphery. SST-like immunoreactivity, however, was induced in the proximal midgut in SSTKO animals, suggesting intestinal expression of a novel SST-like gene."xsd:string |
| http://purl.uniprot.org/citations/12145348 | http://purl.org/dc/terms/identifier | "doi:10.1210/me.2002-0068"xsd:string |
| http://purl.uniprot.org/citations/12145348 | http://purl.uniprot.org/core/author | "Ramirez J.L."xsd:string |
| http://purl.uniprot.org/citations/12145348 | http://purl.uniprot.org/core/author | "Rubinstein M."xsd:string |
| http://purl.uniprot.org/citations/12145348 | http://purl.uniprot.org/core/author | "Patel Y.C."xsd:string |
| http://purl.uniprot.org/citations/12145348 | http://purl.uniprot.org/core/author | "Kumar U."xsd:string |
| http://purl.uniprot.org/citations/12145348 | http://purl.uniprot.org/core/author | "Low M.J."xsd:string |
| http://purl.uniprot.org/citations/12145348 | http://purl.uniprot.org/core/author | "Mouchantaf R."xsd:string |
| http://purl.uniprot.org/citations/12145348 | http://purl.uniprot.org/core/author | "Otero Corchon V."xsd:string |
| http://purl.uniprot.org/citations/12145348 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12145348 | http://purl.uniprot.org/core/name | "Mol Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/12145348 | http://purl.uniprot.org/core/pages | "1951-1963"xsd:string |
| http://purl.uniprot.org/citations/12145348 | http://purl.uniprot.org/core/title | "Brain somatostatin receptors are up-regulated in somatostatin-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/12145348 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/12145348 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12145348 |
| http://purl.uniprot.org/citations/12145348 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12145348 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1D6-mappedCitation-12145348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12145348 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHZ3-mappedCitation-12145348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12145348 |
| http://purl.uniprot.org/uniprot/#_D7NVX2-mappedCitation-12145348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12145348 |
| http://purl.uniprot.org/uniprot/#_D7NVX3-mappedCitation-12145348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12145348 |
| http://purl.uniprot.org/uniprot/#_O08858-mappedCitation-12145348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12145348 |
| http://purl.uniprot.org/uniprot/#_O35715-mappedCitation-12145348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12145348 |
| http://purl.uniprot.org/uniprot/#_P30873-mappedCitation-12145348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12145348 |
| http://purl.uniprot.org/uniprot/#_P30875-mappedCitation-12145348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12145348 |