| http://purl.uniprot.org/citations/12145692 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12145692 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12145692 | http://www.w3.org/2000/01/rdf-schema#comment | "The balance between hematopoietic cell viability and apoptosis is regulated by exogenous growth factors, however, the molecular mechanisms by which these trophic factors exert their effects remain obscure. A functional retroviral cDNA library-based screen was employed to identify genes that prevent growth factor withdrawal-mediated apoptosis in the myeloid progenitor cell 32Dcl3. This approach identified three classes of genes: those with known roles in apoptosis (bcl-X(L) and ornithine decarboxylase); genes previously identified but not linked directly to apoptotic signaling (O-linked N-acetylglucosamine transferase); and a previously uncharacterized gene we termed SPIN-2. In 32Dcl3 cells, expression of exogenous SPIN-2 provides 25% protection from apoptosis following growth factor withdrawal compared to controls which show approximately 1-2% survival. SPIN-2 overexpression slows cell growth rates and increases the percentage of cells in G(2)/M (32% vs control cells at 12%). Immunolocalization studies indicate that myc-epitope tagged SPIN-2 proteins, which retain their anti-apoptotic function, reside in the nucleus, whereas a C-terminal deletion mutant that loses its anti-apoptotic activity is located in the cytoplasm. These studies suggest that SPIN-2 is a novel nuclear protein that functions to regulate cell cycle progression and this activity is related to the inhibition of apoptosis following the removal of essential growth factors."xsd:string |
| http://purl.uniprot.org/citations/12145692 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.leu.2402557"xsd:string |
| http://purl.uniprot.org/citations/12145692 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.leu.2402557"xsd:string |
| http://purl.uniprot.org/citations/12145692 | http://purl.uniprot.org/core/author | "Nolan G.P."xsd:string |
| http://purl.uniprot.org/citations/12145692 | http://purl.uniprot.org/core/author | "Nolan G.P."xsd:string |
| http://purl.uniprot.org/citations/12145692 | http://purl.uniprot.org/core/author | "Fletcher B.S."xsd:string |
| http://purl.uniprot.org/citations/12145692 | http://purl.uniprot.org/core/author | "Fletcher B.S."xsd:string |
| http://purl.uniprot.org/citations/12145692 | http://purl.uniprot.org/core/author | "Dragstedt C."xsd:string |
| http://purl.uniprot.org/citations/12145692 | http://purl.uniprot.org/core/author | "Dragstedt C."xsd:string |
| http://purl.uniprot.org/citations/12145692 | http://purl.uniprot.org/core/author | "Notterpek L."xsd:string |
| http://purl.uniprot.org/citations/12145692 | http://purl.uniprot.org/core/author | "Notterpek L."xsd:string |
| http://purl.uniprot.org/citations/12145692 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12145692 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12145692 | http://purl.uniprot.org/core/name | "Leukemia"xsd:string |
| http://purl.uniprot.org/citations/12145692 | http://purl.uniprot.org/core/name | "Leukemia"xsd:string |
| http://purl.uniprot.org/citations/12145692 | http://purl.uniprot.org/core/pages | "1507-1518"xsd:string |
| http://purl.uniprot.org/citations/12145692 | http://purl.uniprot.org/core/pages | "1507-1518"xsd:string |
| http://purl.uniprot.org/citations/12145692 | http://purl.uniprot.org/core/title | "Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with roles in cell cycle progression."xsd:string |
| http://purl.uniprot.org/citations/12145692 | http://purl.uniprot.org/core/title | "Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with roles in cell cycle progression."xsd:string |
| http://purl.uniprot.org/citations/12145692 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/12145692 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/12145692 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12145692 |
| http://purl.uniprot.org/citations/12145692 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12145692 |