| http://purl.uniprot.org/citations/12147629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12147629 | http://www.w3.org/2000/01/rdf-schema#comment | "HHD transgenic mice which express HLA-A2.1 monochain molecules in a H-2 class I(-) context have an improved capacity to develop HLA-A2.1-restricted cytotoxic T lymphocyte (CTL) responses as compared with classical A2.1/K(b) transgenic mice, which express heterodimeric HLA-A2.1 molecules in a H-2 class I wild-type context. A detailed TCR analysis of HLA-A2.1-restricted CD8(+) T cells educated and mobilized in both strains of mice was undertaken. Focusing on TCR beta chains, comparative PCR analysis of naive and immune CD8(+) T cell repertoires were performed. In spite of lower cell surface expression of HLA class I molecules and lower overall number of CD8(+) T cells, HHD mice educate a qualitatively normally diversified CD8(+) T cell repertoire and mobilize a larger variety of CD8(+) T cells in response to HLA-A2.1-restricted antigens compared with A2.1/K(b) mice. These observations provide the molecular bases accounting for the fact that HHD mice represent the most versatile animal model currently available for preclinical studies of HLA-A2.1-restricted CTL responses."xsd:string |
| http://purl.uniprot.org/citations/12147629 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/dxf056"xsd:string |
| http://purl.uniprot.org/citations/12147629 | http://purl.uniprot.org/core/author | "Cochet M."xsd:string |
| http://purl.uniprot.org/citations/12147629 | http://purl.uniprot.org/core/author | "Danos O."xsd:string |
| http://purl.uniprot.org/citations/12147629 | http://purl.uniprot.org/core/author | "Lemonnier F.A."xsd:string |
| http://purl.uniprot.org/citations/12147629 | http://purl.uniprot.org/core/author | "Darche S."xsd:string |
| http://purl.uniprot.org/citations/12147629 | http://purl.uniprot.org/core/author | "Garcia-Pons F."xsd:string |
| http://purl.uniprot.org/citations/12147629 | http://purl.uniprot.org/core/author | "Firat H."xsd:string |
| http://purl.uniprot.org/citations/12147629 | http://purl.uniprot.org/core/author | "Langlade-Demoyen P."xsd:string |
| http://purl.uniprot.org/citations/12147629 | http://purl.uniprot.org/core/author | "Rohrlich P.S."xsd:string |
| http://purl.uniprot.org/citations/12147629 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12147629 | http://purl.uniprot.org/core/name | "Int Immunol"xsd:string |
| http://purl.uniprot.org/citations/12147629 | http://purl.uniprot.org/core/pages | "925-934"xsd:string |
| http://purl.uniprot.org/citations/12147629 | http://purl.uniprot.org/core/title | "Comparative analysis of the CD8(+) T cell repertoires of H-2 class I wild-type/HLA-A2.1 and H-2 class I knockout/HLA-A2.1 transgenic mice."xsd:string |
| http://purl.uniprot.org/citations/12147629 | http://purl.uniprot.org/core/volume | "14"xsd:string |
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