| http://purl.uniprot.org/citations/12149264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12149264 | http://www.w3.org/2000/01/rdf-schema#comment | "We have previously shown that cyclin E can malignantly transform primary rat embryo fibroblasts in cooperation with constitutively active Ha-Ras. In addition, we demonstrated that high level cyclin E expression potentiates the development of methyl-nitroso-urea-induced T-cell lymphomas in mice. To further investigate the mechanism underlying cyclin E-mediated malignant transformation, we have performed a mutational analysis of cyclin E function. Here we show that cyclin E mutants defective to form an active kinase complex with Cdk2 are unable to drive cells from G(1) into S phase but can still malignantly transform rat embryo fibroblasts in cooperation with Ha-Ras. In addition, Cdk2 activation is not a prerequisite for the ability of cyclin E to rescue yeast triple cln mutations. We also find that the oncogenic properties of cyclin E did not entirely correspond with its ability to interact with the negative cell cycle regulator p27(Kip1) or the pocket protein p130. These findings suggest that the oncogenic activity of cyclin E does not exclusively rely on its ability as a positive regulator of G(1) progression. Rather, we propose that cyclin E harbors other functions, independent of Cdk2 activation and p27(Kip1) binding, that contribute significantly to its oncogenic activity."xsd:string |
| http://purl.uniprot.org/citations/12149264 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m205919200"xsd:string |
| http://purl.uniprot.org/citations/12149264 | http://purl.uniprot.org/core/author | "Geisen C."xsd:string |
| http://purl.uniprot.org/citations/12149264 | http://purl.uniprot.org/core/author | "Moroy T."xsd:string |
| http://purl.uniprot.org/citations/12149264 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12149264 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12149264 | http://purl.uniprot.org/core/pages | "39909-39918"xsd:string |
| http://purl.uniprot.org/citations/12149264 | http://purl.uniprot.org/core/title | "The oncogenic activity of cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein."xsd:string |
| http://purl.uniprot.org/citations/12149264 | http://purl.uniprot.org/core/volume | "277"xsd:string |
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