| http://purl.uniprot.org/citations/12150907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12150907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12150907 | http://www.w3.org/2000/01/rdf-schema#comment | "Unfolded Pael receptor (Pael-R) is a substrate of the E3 ubiquitin ligase Parkin. Accumulation of Pael-R in the endoplasmic reticulum (ER) of dopaminergic neurons induces ER stress leading to neurodegeneration. Here, we show that CHIP, Hsp70, Parkin, and Pael-R formed a complex in vitro and in vivo. The amount of CHIP in the complex was increased during ER stress. CHIP promoted the dissociation of Hsp70 from Parkin and Pael-R, thus facilitating Parkin-mediated Pael-R ubiquitination. Moreover, CHIP enhanced Parkin-mediated in vitro ubiquitination of Pael-R in the absence of Hsp70. Furthermore, CHIP enhanced the ability of Parkin to inhibit cell death induced by Pael-R. Taken together, these results indicate that CHIP is a mammalian E4-like molecule that positively regulates Parkin E3 activity."xsd:string |
| http://purl.uniprot.org/citations/12150907 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(02)00583-x"xsd:string |
| http://purl.uniprot.org/citations/12150907 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(02)00583-x"xsd:string |
| http://purl.uniprot.org/citations/12150907 | http://purl.uniprot.org/core/author | "Imai Y."xsd:string |
| http://purl.uniprot.org/citations/12150907 | http://purl.uniprot.org/core/author | "Imai Y."xsd:string |
| http://purl.uniprot.org/citations/12150907 | http://purl.uniprot.org/core/author | "Nakayama K."xsd:string |
| http://purl.uniprot.org/citations/12150907 | http://purl.uniprot.org/core/author | "Nakayama K."xsd:string |
| http://purl.uniprot.org/citations/12150907 | http://purl.uniprot.org/core/author | "Takahashi R."xsd:string |
| http://purl.uniprot.org/citations/12150907 | http://purl.uniprot.org/core/author | "Takahashi R."xsd:string |
| http://purl.uniprot.org/citations/12150907 | http://purl.uniprot.org/core/author | "Soda M."xsd:string |
| http://purl.uniprot.org/citations/12150907 | http://purl.uniprot.org/core/author | "Soda M."xsd:string |
| http://purl.uniprot.org/citations/12150907 | http://purl.uniprot.org/core/author | "Hatakeyama S."xsd:string |
| http://purl.uniprot.org/citations/12150907 | http://purl.uniprot.org/core/author | "Hatakeyama S."xsd:string |
| http://purl.uniprot.org/citations/12150907 | http://purl.uniprot.org/core/author | "Hashikawa T."xsd:string |
| http://purl.uniprot.org/citations/12150907 | http://purl.uniprot.org/core/author | "Hashikawa T."xsd:string |
| http://purl.uniprot.org/citations/12150907 | http://purl.uniprot.org/core/author | "Akagi T."xsd:string |
| http://purl.uniprot.org/citations/12150907 | http://purl.uniprot.org/core/author | "Akagi T."xsd:string |
| http://purl.uniprot.org/citations/12150907 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12150907 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12150907 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/12150907 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/12150907 | http://purl.uniprot.org/core/pages | "55-67"xsd:string |
| http://purl.uniprot.org/citations/12150907 | http://purl.uniprot.org/core/pages | "55-67"xsd:string |