| http://purl.uniprot.org/citations/12150915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12150915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12150915 | http://www.w3.org/2000/01/rdf-schema#comment | "The S/T-protein kinases activated by phosphoinositide 3-kinase (PI3K) regulate a myriad of cellular processes. Here, we show that an approach using a combination of biochemistry and bioinformatics can identify substrates of these kinases. This approach identifies the tuberous sclerosis complex-2 gene product, tuberin, as a potential target of Akt/PKB. We demonstrate that, upon activation of PI3K, tuberin is phosphorylated on consensus recognition sites for PI3K-dependent S/T kinases. Moreover, Akt/PKB can phosphorylate tuberin in vitro and in vivo. We also show that S939 and T1462 of tuberin are PI3K-regulated phosphorylation sites and that T1462 is constitutively phosphorylated in PTEN(-/-) tumor-derived cell lines. Finally, we find that a tuberin mutant lacking the major PI3K-dependent phosphorylation sites can block the activation of S6K1, suggesting a means by which the PI3K-Akt pathway regulates S6K1 activity."xsd:string |
| http://purl.uniprot.org/citations/12150915 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(02)00568-3"xsd:string |
| http://purl.uniprot.org/citations/12150915 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(02)00568-3"xsd:string |
| http://purl.uniprot.org/citations/12150915 | http://purl.uniprot.org/core/author | "Cantley L.C."xsd:string |
| http://purl.uniprot.org/citations/12150915 | http://purl.uniprot.org/core/author | "Cantley L.C."xsd:string |
| http://purl.uniprot.org/citations/12150915 | http://purl.uniprot.org/core/author | "Blenis J."xsd:string |
| http://purl.uniprot.org/citations/12150915 | http://purl.uniprot.org/core/author | "Blenis J."xsd:string |
| http://purl.uniprot.org/citations/12150915 | http://purl.uniprot.org/core/author | "Logsdon M.N."xsd:string |
| http://purl.uniprot.org/citations/12150915 | http://purl.uniprot.org/core/author | "Logsdon M.N."xsd:string |
| http://purl.uniprot.org/citations/12150915 | http://purl.uniprot.org/core/author | "Manning B.D."xsd:string |
| http://purl.uniprot.org/citations/12150915 | http://purl.uniprot.org/core/author | "Manning B.D."xsd:string |
| http://purl.uniprot.org/citations/12150915 | http://purl.uniprot.org/core/author | "Tee A.R."xsd:string |
| http://purl.uniprot.org/citations/12150915 | http://purl.uniprot.org/core/author | "Tee A.R."xsd:string |
| http://purl.uniprot.org/citations/12150915 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12150915 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12150915 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/12150915 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/12150915 | http://purl.uniprot.org/core/pages | "151-162"xsd:string |
| http://purl.uniprot.org/citations/12150915 | http://purl.uniprot.org/core/pages | "151-162"xsd:string |
| http://purl.uniprot.org/citations/12150915 | http://purl.uniprot.org/core/title | "Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway."xsd:string |
| http://purl.uniprot.org/citations/12150915 | http://purl.uniprot.org/core/title | "Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway."xsd:string |
| http://purl.uniprot.org/citations/12150915 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/12150915 | http://purl.uniprot.org/core/volume | "10"xsd:string |