| http://purl.uniprot.org/citations/12150927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12150927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12150927 | http://www.w3.org/2000/01/rdf-schema#comment | "Toll-like receptors (TLRs) detect microorganisms and protect multicellular organisms from infection. TLRs transduce their signals through MyD88 and the serine/threonine kinase IRAK. The IRAK family consists of two active kinases, IRAK and IRAK-4, and two inactive kinases, IRAK-2 and IRAK-M. IRAK-M expression is restricted to monocytes/macrophages, whereas other IRAKs are ubiquitous. We show here that IRAK-M is induced upon TLR stimulation and negatively regulates TLR signaling. IRAK-M prevented dissociation of IRAK and IRAK-4 from MyD88 and formation of IRAK-TRAF6 complexes. IRAK-M(-/-) cells exhibited increased cytokine production upon TLR/IL-1 stimulation and bacterial challenge, and IRAK-M(-/-) mice showed increased inflammatory responses to bacterial infection. Endotoxin tolerance, a protection mechanism against endotoxin shock, was significantly reduced in IRAK-M(-/-) cells. Thus, IRAK-M regulates TLR signaling and innate immune homeostasis."xsd:string |
| http://purl.uniprot.org/citations/12150927 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(02)00827-9"xsd:string |
| http://purl.uniprot.org/citations/12150927 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(02)00827-9"xsd:string |
| http://purl.uniprot.org/citations/12150927 | http://purl.uniprot.org/core/author | "Kobayashi K."xsd:string |
| http://purl.uniprot.org/citations/12150927 | http://purl.uniprot.org/core/author | "Kobayashi K."xsd:string |
| http://purl.uniprot.org/citations/12150927 | http://purl.uniprot.org/core/author | "Galan J.E."xsd:string |
| http://purl.uniprot.org/citations/12150927 | http://purl.uniprot.org/core/author | "Galan J.E."xsd:string |
| http://purl.uniprot.org/citations/12150927 | http://purl.uniprot.org/core/author | "Flavell R.A."xsd:string |
| http://purl.uniprot.org/citations/12150927 | http://purl.uniprot.org/core/author | "Flavell R.A."xsd:string |
| http://purl.uniprot.org/citations/12150927 | http://purl.uniprot.org/core/author | "Medzhitov R."xsd:string |
| http://purl.uniprot.org/citations/12150927 | http://purl.uniprot.org/core/author | "Medzhitov R."xsd:string |
| http://purl.uniprot.org/citations/12150927 | http://purl.uniprot.org/core/author | "Hernandez L.D."xsd:string |
| http://purl.uniprot.org/citations/12150927 | http://purl.uniprot.org/core/author | "Hernandez L.D."xsd:string |
| http://purl.uniprot.org/citations/12150927 | http://purl.uniprot.org/core/author | "Janeway C.A. Jr."xsd:string |
| http://purl.uniprot.org/citations/12150927 | http://purl.uniprot.org/core/author | "Janeway C.A. Jr."xsd:string |
| http://purl.uniprot.org/citations/12150927 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12150927 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12150927 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/12150927 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/12150927 | http://purl.uniprot.org/core/pages | "191-202"xsd:string |
| http://purl.uniprot.org/citations/12150927 | http://purl.uniprot.org/core/pages | "191-202"xsd:string |
| http://purl.uniprot.org/citations/12150927 | http://purl.uniprot.org/core/title | "IRAK-M is a negative regulator of Toll-like receptor signaling."xsd:string |
| http://purl.uniprot.org/citations/12150927 | http://purl.uniprot.org/core/title | "IRAK-M is a negative regulator of Toll-like receptor signaling."xsd:string |