| http://purl.uniprot.org/citations/12150997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12150997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12150997 | http://www.w3.org/2000/01/rdf-schema#comment | "Defining the molecular mechanisms that integrate diverse signaling pathways at the level of gene transcription remains a central issue in biology. Here, we demonstrate that interleukin-1beta (IL-1beta) causes nuclear export of a specific N-CoR corepressor complex, resulting in derepression of a specific subset of NF-kappaB-regulated genes, exemplified by the tetraspanin KAI1 that regulates membrane receptor function. Nuclear export of the N-CoR/TAB2/HDAC3 complex by IL-1beta is temporally linked to selective recruitment of a Tip60 coactivator complex. Surprisingly, KAI1 is also directly activated by a ternary complex, dependent on the acetyltransferase activity of Tip60, consisting of the presenilin-dependent C-terminal cleavage product of the amyloid beta precursor protein (APP), Fe65, and Tip60, identifying a specific in vivo gene target of an APP-dependent transcription complex in the brain."xsd:string |
| http://purl.uniprot.org/citations/12150997 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(02)00809-7"xsd:string |
| http://purl.uniprot.org/citations/12150997 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(02)00809-7"xsd:string |
| http://purl.uniprot.org/citations/12150997 | http://purl.uniprot.org/core/author | "Koo E.H."xsd:string |
| http://purl.uniprot.org/citations/12150997 | http://purl.uniprot.org/core/author | "Koo E.H."xsd:string |
| http://purl.uniprot.org/citations/12150997 | http://purl.uniprot.org/core/author | "Rosenfeld M.G."xsd:string |
| http://purl.uniprot.org/citations/12150997 | http://purl.uniprot.org/core/author | "Rosenfeld M.G."xsd:string |
| http://purl.uniprot.org/citations/12150997 | http://purl.uniprot.org/core/author | "Glass C.K."xsd:string |
| http://purl.uniprot.org/citations/12150997 | http://purl.uniprot.org/core/author | "Glass C.K."xsd:string |
| http://purl.uniprot.org/citations/12150997 | http://purl.uniprot.org/core/author | "Ohgi K.A."xsd:string |
| http://purl.uniprot.org/citations/12150997 | http://purl.uniprot.org/core/author | "Ohgi K.A."xsd:string |
| http://purl.uniprot.org/citations/12150997 | http://purl.uniprot.org/core/author | "Rose D.W."xsd:string |
| http://purl.uniprot.org/citations/12150997 | http://purl.uniprot.org/core/author | "Rose D.W."xsd:string |
| http://purl.uniprot.org/citations/12150997 | http://purl.uniprot.org/core/author | "Baek S.H."xsd:string |
| http://purl.uniprot.org/citations/12150997 | http://purl.uniprot.org/core/author | "Baek S.H."xsd:string |
| http://purl.uniprot.org/citations/12150997 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12150997 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12150997 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/12150997 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/12150997 | http://purl.uniprot.org/core/pages | "55-67"xsd:string |
| http://purl.uniprot.org/citations/12150997 | http://purl.uniprot.org/core/pages | "55-67"xsd:string |
| http://purl.uniprot.org/citations/12150997 | http://purl.uniprot.org/core/title | "Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein."xsd:string |
| http://purl.uniprot.org/citations/12150997 | http://purl.uniprot.org/core/title | "Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein."xsd:string |