| http://purl.uniprot.org/citations/12161440 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12161440 | http://www.w3.org/2000/01/rdf-schema#comment | "Developing Dictyostelium cells form evenly sized groups of approximately 2 x 10(4) cells. A secreted 450-kDa protein complex called counting factor (CF) regulates group size by repressing cell-cell adhesion and myosin polymerization and by increasing cAMP-stimulated cAMP production, actin polymerization, and cell motility. We find that CF regulates group size in part by repressing internal glucose levels. Transformants lacking bioactive CF and wild-type cells with extracellular CF depleted by antibodies have high glucose levels, whereas transformants oversecreting CF have low glucose levels. A component of CF, countin, affects group size in a manner similar to CF, and a 1-min exposure of cells to countin decreases glucose levels. Adding 1 mm exogenous glucose negates the effect of high levels of extracellular CF on group size and mimics the effect of depleting CF on glucose levels, cell-cell adhesion, cAMP pulse size, actin polymerization, myosin assembly, and motility. These results suggest that glucose is a downstream component in part of the CF signaling pathway and may be relevant to the observed role of the insulin pathway in tissue size regulation in higher eukaryotes."xsd:string |
| http://purl.uniprot.org/citations/12161440 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m205635200"xsd:string |
| http://purl.uniprot.org/citations/12161440 | http://purl.uniprot.org/core/author | "Gomer R.H."xsd:string |
| http://purl.uniprot.org/citations/12161440 | http://purl.uniprot.org/core/author | "Jang W."xsd:string |
| http://purl.uniprot.org/citations/12161440 | http://purl.uniprot.org/core/author | "Chiem B."xsd:string |
| http://purl.uniprot.org/citations/12161440 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12161440 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12161440 | http://purl.uniprot.org/core/pages | "39202-39208"xsd:string |
| http://purl.uniprot.org/citations/12161440 | http://purl.uniprot.org/core/title | "A secreted cell number counting factor represses intracellular glucose levels to regulate group size in dictyostelium."xsd:string |
| http://purl.uniprot.org/citations/12161440 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/12161440 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12161440 |
| http://purl.uniprot.org/citations/12161440 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12161440 |
| http://purl.uniprot.org/uniprot/#_Q86IV5-mappedCitation-12161440 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12161440 |
| http://purl.uniprot.org/uniprot/Q86IV5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12161440 |