| http://purl.uniprot.org/citations/12162881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12162881 | http://www.w3.org/2000/01/rdf-schema#comment | "We described the interferon (IFN) regulatory factor-1 (IRF-1) promoter single nucleotide polymorphisms (SNPs), and the clinical and immunologic implications of these SNPs have been investigated. We successfully determined the mutation at -300 of the IRF-1 promoter by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and this mutation linked with other mutations in the promoter region. In our Japanese population, the frequency of the type -300*A/A was 11.9%, type A/G was 54.2%, and type G/G was 33.9%. We found no significant difference without IFN stimulation in the production levels of IFN-gamma and interleukin-10 (IL-10) from peripheral blood mononuclear cells (PBMC) between subjects with -300*A/A and those with other types. IFN-alpha stimulation, however, increased the levels of IFN-gamma significantly and decreased the IL-10 production level significantly only in the subject with -300*A/A type. Flow cytometric analysis showed that the Th1-type CD4(+) cell population was significantly increased by IFN-beta administration only in the patient with chronic hepatitis C with -300*A/A type. These results suggest that the IRF-1 promoter SNP types are positively involved in Th1-type response and, consequently, the -300*A/A type may be beneficial for viral elimination in chronic hepatitis C and IFN therapy."xsd:string |
| http://purl.uniprot.org/citations/12162881 | http://purl.org/dc/terms/identifier | "doi:10.1089/10799900260100196"xsd:string |
| http://purl.uniprot.org/citations/12162881 | http://purl.uniprot.org/core/author | "Nakamura M."xsd:string |
| http://purl.uniprot.org/citations/12162881 | http://purl.uniprot.org/core/author | "Takahashi M."xsd:string |
| http://purl.uniprot.org/citations/12162881 | http://purl.uniprot.org/core/author | "Saito H."xsd:string |
| http://purl.uniprot.org/citations/12162881 | http://purl.uniprot.org/core/author | "Wakabayashi K."xsd:string |
| http://purl.uniprot.org/citations/12162881 | http://purl.uniprot.org/core/author | "Tada S."xsd:string |
| http://purl.uniprot.org/citations/12162881 | http://purl.uniprot.org/core/author | "Ebinuma H."xsd:string |
| http://purl.uniprot.org/citations/12162881 | http://purl.uniprot.org/core/author | "Ishii H."xsd:string |
| http://purl.uniprot.org/citations/12162881 | http://purl.uniprot.org/core/author | "Nakamoto N."xsd:string |
| http://purl.uniprot.org/citations/12162881 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12162881 | http://purl.uniprot.org/core/name | "J Interferon Cytokine Res"xsd:string |
| http://purl.uniprot.org/citations/12162881 | http://purl.uniprot.org/core/pages | "693-700"xsd:string |
| http://purl.uniprot.org/citations/12162881 | http://purl.uniprot.org/core/title | "The detection of IRF-1 promoter polymorphisms and their possible contribution to T helper 1 response in chronic hepatitis C."xsd:string |
| http://purl.uniprot.org/citations/12162881 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12162881 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12162881 |
| http://purl.uniprot.org/citations/12162881 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12162881 |
| http://purl.uniprot.org/uniprot/#_A0A0B6XK53-mappedCitation-12162881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12162881 |
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| http://purl.uniprot.org/uniprot/#_A0A510GDD8-mappedCitation-12162881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12162881 |
| http://purl.uniprot.org/uniprot/#_B4DQF0-mappedCitation-12162881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12162881 |
| http://purl.uniprot.org/uniprot/#_P10914-mappedCitation-12162881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12162881 |
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