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http://purl.uniprot.org/citations/12163015http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12163015http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12163015http://www.w3.org/2000/01/rdf-schema#comment"The Drosophila crooked neck (crn) gene encodes an unusual TPR-containing protein whose function is essential for embryonic development. Homology with other TPR-proteins involved in cell cycle control, initially led to the proposal that Crn might play a critical role in regulation of embryonic cell divisions. Here, we show that Crn does not have a cell cycle function in the embryo. By using specific antibodies we also show that the Crn protein is a nuclear protein which localizes in "speckles" which could correspond to preferential localization of several other splicing factors. Fractionation of nuclear extracts on sucrose gradients revealed Crn in a 900 kDa multiproteic complex together with snRNPs, suggesting that Crn participates in the assembly of the splicing machinery in vivo."xsd:string
http://purl.uniprot.org/citations/12163015http://purl.org/dc/terms/identifier"doi:10.1016/s0006-291x(02)00863-x"xsd:string
http://purl.uniprot.org/citations/12163015http://purl.org/dc/terms/identifier"doi:10.1016/s0006-291x(02)00863-x"xsd:string
http://purl.uniprot.org/citations/12163015http://purl.uniprot.org/core/author"Leopold P."xsd:string
http://purl.uniprot.org/citations/12163015http://purl.uniprot.org/core/author"Leopold P."xsd:string
http://purl.uniprot.org/citations/12163015http://purl.uniprot.org/core/author"Raisin-Tani S."xsd:string
http://purl.uniprot.org/citations/12163015http://purl.uniprot.org/core/author"Raisin-Tani S."xsd:string
http://purl.uniprot.org/citations/12163015http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/12163015http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/12163015http://purl.uniprot.org/core/name"Biochem. Biophys. Res. Commun."xsd:string
http://purl.uniprot.org/citations/12163015http://purl.uniprot.org/core/name"Biochem. Biophys. Res. Commun."xsd:string
http://purl.uniprot.org/citations/12163015http://purl.uniprot.org/core/pages"288-292"xsd:string
http://purl.uniprot.org/citations/12163015http://purl.uniprot.org/core/pages"288-292"xsd:string
http://purl.uniprot.org/citations/12163015http://purl.uniprot.org/core/title"Drosophila crooked-neck protein co-fractionates in a multiprotein complex with splicing factors."xsd:string
http://purl.uniprot.org/citations/12163015http://purl.uniprot.org/core/title"Drosophila crooked-neck protein co-fractionates in a multiprotein complex with splicing factors."xsd:string
http://purl.uniprot.org/citations/12163015http://purl.uniprot.org/core/volume"296"xsd:string
http://purl.uniprot.org/citations/12163015http://purl.uniprot.org/core/volume"296"xsd:string
http://purl.uniprot.org/citations/12163015http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12163015
http://purl.uniprot.org/citations/12163015http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12163015
http://purl.uniprot.org/citations/12163015http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/12163015
http://purl.uniprot.org/citations/12163015http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/12163015
http://purl.uniprot.org/uniprot/P17886http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/12163015
http://purl.uniprot.org/uniprot/P17886#attribution-32A2C82327FD7E146E2D550FD86F3662http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/12163015