| http://purl.uniprot.org/citations/12163500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12163500 | http://www.w3.org/2000/01/rdf-schema#comment | "Surfactant protein D (SP-D) gene-targeted mice develop severe pulmonary disease associated with emphysema, pulmonary lipidosis, and foamy macrophage infiltrations. To determine the potential reversibility of these abnormalities, transgenic mice were developed in which SP-D was conditionally replaced in the respiratory epithelium of SP-D(-/-) mice. SP-D was not detected in the absence of doxycycline. Treatment with doxycycline after birth restored pulmonary SP-D concentrations and corrected pulmonary pathology at adulthood. When SP-D was replaced in adult SP-D(-/-) mice, alveolar SP-D was restored within 3 days, pulmonary lipid abnormalities were corrected, but emphysema persisted. In corrected adult SP-D(-/-) mice, loss of SP-D caused focal emphysema and pulmonary inflammation but did not cause phospholipid abnormalities characteristic of SP-D(-/-) mice. Thus, abnormalities in surfactant phospholipid homeostasis and alveolar macrophage abnormalities were readily corrected by restoration of SP-D. However, once established, emphysema was not reversed by SP-D. SP-D-dependent processes regulating surfactant lipid homeostasis were disassociated from those mediating emphysema."xsd:string |
| http://purl.uniprot.org/citations/12163500 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m206200200"xsd:string |
| http://purl.uniprot.org/citations/12163500 | http://purl.uniprot.org/core/author | "Ikegami M."xsd:string |
| http://purl.uniprot.org/citations/12163500 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/12163500 | http://purl.uniprot.org/core/author | "Whitsett J.A."xsd:string |
| http://purl.uniprot.org/citations/12163500 | http://purl.uniprot.org/core/author | "Dey C.R."xsd:string |
| http://purl.uniprot.org/citations/12163500 | http://purl.uniprot.org/core/author | "Korfhagen T.R."xsd:string |
| http://purl.uniprot.org/citations/12163500 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12163500 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12163500 | http://purl.uniprot.org/core/pages | "38709-38713"xsd:string |
| http://purl.uniprot.org/citations/12163500 | http://purl.uniprot.org/core/title | "Reversibility of pulmonary abnormalities by conditional replacement of surfactant protein D (SP-D) in vivo."xsd:string |
| http://purl.uniprot.org/citations/12163500 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/12163500 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12163500 |
| http://purl.uniprot.org/citations/12163500 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12163500 |
| http://purl.uniprot.org/uniprot/#_P50404-mappedCitation-12163500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12163500 |
| http://purl.uniprot.org/uniprot/P50404 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12163500 |