| http://purl.uniprot.org/citations/12163605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12163605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12163605 | http://www.w3.org/2000/01/rdf-schema#comment | "Human immunodeficiency virus type 1 (HIV-1) virions bind to B cells in the peripheral blood and lymph nodes through interactions between CD21 on B cells and complement-complexed virions. B-cell-bound virions have been shown to be highly infectious, suggesting a unique mode of HIV-1 dissemination by B cells circulating between peripheral blood and lymphoid tissues. In order to investigate the relationship between B-cell-bound HIV-1 and viruses found in CD4+ T cells and in plasma, we examined the genetic relationships of HIV-1 found in the blood and lymph nodes of chronically infected patients with heteroduplex mobility and tracking assays and DNA sequence analysis. In samples from 13 of 15 patients examined, HIV-1 variants in peripheral blood-derived B cells were closely related to virus in CD4+ T cells and more divergent from virus in plasma. In samples from five chronically viremic patients for whom analyses were extended to include lymph node-derived HIV-1 isolates, B-cell-associated HIV-1 and CD4+-T-cell-associated HIV-1 in the lymph nodes were equivalent in their divergence from virus in peripheral blood-derived B cells and generally more distantly related to virus in peripheral blood-derived CD4+ T cells. These results indicates virologic cross talk between B cells and CD4+ T cells within the microenvironment of lymphoid tissues and, to a lesser extent, between cells in lymph nodes and the peripheral blood. These findings also indicate that most of the virus in plasma originates from cells other than CD4(+) T cells in the peripheral blood and lymph nodes."xsd:string |
| http://purl.uniprot.org/citations/12163605 | http://purl.org/dc/terms/identifier | "doi:10.1128/JVI.76.17.8855-8863.2002"xsd:string |
| http://purl.uniprot.org/citations/12163605 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.76.17.8855-8863.2002"xsd:string |
| http://purl.uniprot.org/citations/12163605 | http://purl.uniprot.org/core/author | "Liu S."xsd:string |
| http://purl.uniprot.org/citations/12163605 | http://purl.uniprot.org/core/author | "Liu S."xsd:string |
| http://purl.uniprot.org/citations/12163605 | http://purl.uniprot.org/core/author | "Malaspina A."xsd:string |
| http://purl.uniprot.org/citations/12163605 | http://purl.uniprot.org/core/author | "Malaspina A."xsd:string |
| http://purl.uniprot.org/citations/12163605 | http://purl.uniprot.org/core/author | "Fauci A.S."xsd:string |
| http://purl.uniprot.org/citations/12163605 | http://purl.uniprot.org/core/author | "Fauci A.S."xsd:string |
| http://purl.uniprot.org/citations/12163605 | http://purl.uniprot.org/core/author | "Mullins J.I."xsd:string |
| http://purl.uniprot.org/citations/12163605 | http://purl.uniprot.org/core/author | "Mullins J.I."xsd:string |
| http://purl.uniprot.org/citations/12163605 | http://purl.uniprot.org/core/author | "Moir S."xsd:string |
| http://purl.uniprot.org/citations/12163605 | http://purl.uniprot.org/core/author | "Moir S."xsd:string |
| http://purl.uniprot.org/citations/12163605 | http://purl.uniprot.org/core/author | "Chun T.W."xsd:string |
| http://purl.uniprot.org/citations/12163605 | http://purl.uniprot.org/core/author | "Chun T.W."xsd:string |
| http://purl.uniprot.org/citations/12163605 | http://purl.uniprot.org/core/author | "Nickle D.C."xsd:string |
| http://purl.uniprot.org/citations/12163605 | http://purl.uniprot.org/core/author | "Nickle D.C."xsd:string |
| http://purl.uniprot.org/citations/12163605 | http://purl.uniprot.org/core/author | "Donoghue E.T."xsd:string |
| http://purl.uniprot.org/citations/12163605 | http://purl.uniprot.org/core/author | "Donoghue E.T."xsd:string |
| http://purl.uniprot.org/citations/12163605 | http://purl.uniprot.org/core/author | "Dybul M."xsd:string |
| http://purl.uniprot.org/citations/12163605 | http://purl.uniprot.org/core/author | "Dybul M."xsd:string |
| http://purl.uniprot.org/citations/12163605 | http://purl.uniprot.org/core/author | "Ehler L.A."xsd:string |
| http://purl.uniprot.org/citations/12163605 | http://purl.uniprot.org/core/author | "Ehler L.A."xsd:string |