| http://purl.uniprot.org/citations/12165539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12165539 | http://www.w3.org/2000/01/rdf-schema#comment | "The objective of this study was to systematically assess leukocyte-endothelial cell interactions in vivo in response to LPS in CD14-deficient (CD14(-/-)) and Toll-like receptor 4-deficient (TLR4(d); C3H/HeJ) mice. Local injection of LPS (0.05 micro g/kg) into muscle at a concentration that did not cause systemic effects produced a significant reduction in the speed with which leukocytes roll and a substantial increase in leukocyte adhesion and emigration 4 h postinjection. There was no response to LPS in the muscle microvasculature of CD14(-/-) mice or TLR4(d) animals. Systemic LPS induced leukopenia and significant sequestration of neutrophils in lungs in wild-type mice but not in CD14(-/-) or TLR4(d) mice. P-selectin expression was examined in numerous mouse organs using a dual radiolabeling mAb technique. The results revealed a 20-to 50-fold increase in P-selectin expression in response to LPS in all wild-type tissues examined but no response in any TLR4(d) tissues. Surprisingly, there was consistently a partial, significant increase in P-selectin expression in numerous microvasculatures including skin and pancreas, but no increase in P-selectin was detected in lung, muscle, and other organs in CD14(-/-) mice in response to LPS. Next, the skin and muscle microcirculation were visualized using intravital microscopy after systemic LPS treatment, and the results confirmed a CD14-independent mechanism of leukocyte sequestration in skin but not muscle. In summary, our results suggest that the LPS-induced leukocyte sequestration to some tissues is entirely dependent on both CD14 and TLR4 but there are CD14-independent, TLR4-dependent endothelial cell responses in some microvascular beds."xsd:string |
| http://purl.uniprot.org/citations/12165539 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.169.4.2111"xsd:string |
| http://purl.uniprot.org/citations/12165539 | http://purl.uniprot.org/core/author | "Goyert S.M."xsd:string |
| http://purl.uniprot.org/citations/12165539 | http://purl.uniprot.org/core/author | "Kubes P."xsd:string |
| http://purl.uniprot.org/citations/12165539 | http://purl.uniprot.org/core/author | "Andonegui G."xsd:string |
| http://purl.uniprot.org/citations/12165539 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12165539 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/12165539 | http://purl.uniprot.org/core/pages | "2111-2119"xsd:string |
| http://purl.uniprot.org/citations/12165539 | http://purl.uniprot.org/core/title | "Lipopolysaccharide-induced leukocyte-endothelial cell interactions: a role for CD14 versus toll-like receptor 4 within microvessels."xsd:string |
| http://purl.uniprot.org/citations/12165539 | http://purl.uniprot.org/core/volume | "169"xsd:string |
| http://purl.uniprot.org/citations/12165539 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12165539 |
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