| http://purl.uniprot.org/citations/12165861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12165861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12165861 | http://www.w3.org/2000/01/rdf-schema#comment | "The three human TACC genes encode a family of proteins that are suspected to play a role in carcinogenesis. Their function is not precisely known; a Xenopus TACC protein called Maskin is involved in translational control, while the Drosophila D-TACC associates with microtubules and centrosomes. We have characterized the human TACC1 gene and its products. The TACC1 gene is located in region p12 of chromosome 8; its mRNA is ubiquitously expressed and encodes a protein with an apparent molecular mass of 125 kDa, which is cytoplasmic and mainly perinuclear. We show that TACC1 mRNA gene expression is down-regulated in various types of tumors. Using immunohistochemistry of tumor tissue-microarrays and sections, we confirm that the level of TACC1 protein is down-regulated in breast cancer. Finally, using the two-hybrid screen in yeast, GST pull-downs and co-immunoprecipitations, we identified two potential binding partners for TACC1, LSM7 and SmG. They constitute a conserved subfamily of Sm-like small proteins that associate with U6 snRNPs and play a role in several aspects of mRNA processing. We speculate that down-regulation of TACC1 may alter the control of mRNA homeostasis in polarized cells and participates in the oncogenic processes."xsd:string |
| http://purl.uniprot.org/citations/12165861 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1205658"xsd:string |
| http://purl.uniprot.org/citations/12165861 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1205658"xsd:string |
| http://purl.uniprot.org/citations/12165861 | http://purl.uniprot.org/core/author | "Adelaide J."xsd:string |
| http://purl.uniprot.org/citations/12165861 | http://purl.uniprot.org/core/author | "Adelaide J."xsd:string |
| http://purl.uniprot.org/citations/12165861 | http://purl.uniprot.org/core/author | "Birnbaum D."xsd:string |
| http://purl.uniprot.org/citations/12165861 | http://purl.uniprot.org/core/author | "Birnbaum D."xsd:string |
| http://purl.uniprot.org/citations/12165861 | http://purl.uniprot.org/core/author | "Conte N."xsd:string |
| http://purl.uniprot.org/citations/12165861 | http://purl.uniprot.org/core/author | "Conte N."xsd:string |
| http://purl.uniprot.org/citations/12165861 | http://purl.uniprot.org/core/author | "Delaval B."xsd:string |
| http://purl.uniprot.org/citations/12165861 | http://purl.uniprot.org/core/author | "Delaval B."xsd:string |
| http://purl.uniprot.org/citations/12165861 | http://purl.uniprot.org/core/author | "Ginestier C."xsd:string |
| http://purl.uniprot.org/citations/12165861 | http://purl.uniprot.org/core/author | "Ginestier C."xsd:string |
| http://purl.uniprot.org/citations/12165861 | http://purl.uniprot.org/core/author | "Isnardon D."xsd:string |
| http://purl.uniprot.org/citations/12165861 | http://purl.uniprot.org/core/author | "Isnardon D."xsd:string |
| http://purl.uniprot.org/citations/12165861 | http://purl.uniprot.org/core/author | "Jacquemier J."xsd:string |
| http://purl.uniprot.org/citations/12165861 | http://purl.uniprot.org/core/author | "Jacquemier J."xsd:string |
| http://purl.uniprot.org/citations/12165861 | http://purl.uniprot.org/core/author | "Charafe-Jauffret E."xsd:string |
| http://purl.uniprot.org/citations/12165861 | http://purl.uniprot.org/core/author | "Charafe-Jauffret E."xsd:string |
| http://purl.uniprot.org/citations/12165861 | http://purl.uniprot.org/core/author | "Geneix J."xsd:string |
| http://purl.uniprot.org/citations/12165861 | http://purl.uniprot.org/core/author | "Geneix J."xsd:string |
| http://purl.uniprot.org/citations/12165861 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12165861 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |