| http://purl.uniprot.org/citations/12169691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12169691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12169691 | http://www.w3.org/2000/01/rdf-schema#comment | "The von Hippel-Lindau disease gene (VHL) is the causative gene for most adult renal cancers. However, the mechanism by which VHL protein functions as a renal tumor suppressor remains largely unknown. To identify low occupancy VHL protein partners with potential relevance to renal cancer, we screened a human kidney library against human VHL p30 using a yeast two-hybrid approach. Jade-1 (gene for Apoptosis and Differentiation in Epithelia) encodes a previously uncharacterized 64-kDa protein that interacts strongly with VHL protein and is most highly expressed in kidney. Jade-1 protein is short-lived and contains a candidate destabilizing (PEST) motif and plant homeodomains that are not required for the VHL interaction. Jade-1 is abundant in proximal tubule cells, which are clear-cell renal cancer precursors, and expression increases with differentiation. Jade-1 is expressed in cytoplasm and the nucleus diffusely and in speckles, where it partly colocalizes with VHL. VHL reintroduction into renal cancer cells increases endogenous Jade-1 protein abundance up to 10-fold. Furthermore, VHL increases Jade-1 protein half-life up to 3-fold. Thus, direct protein stabilization is identified as a new VHL function. Moreover, Jade-1 protein represents a novel candidate regulatory factor in VHL-mediated renal tumor suppression."xsd:string |
| http://purl.uniprot.org/citations/12169691 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m205040200"xsd:string |
| http://purl.uniprot.org/citations/12169691 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m205040200"xsd:string |
| http://purl.uniprot.org/citations/12169691 | http://purl.uniprot.org/core/author | "Xu C."xsd:string |
| http://purl.uniprot.org/citations/12169691 | http://purl.uniprot.org/core/author | "Xu C."xsd:string |
| http://purl.uniprot.org/citations/12169691 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/12169691 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/12169691 | http://purl.uniprot.org/core/author | "Kuzmin I."xsd:string |
| http://purl.uniprot.org/citations/12169691 | http://purl.uniprot.org/core/author | "Kuzmin I."xsd:string |
| http://purl.uniprot.org/citations/12169691 | http://purl.uniprot.org/core/author | "Ross J.J."xsd:string |
| http://purl.uniprot.org/citations/12169691 | http://purl.uniprot.org/core/author | "Ross J.J."xsd:string |
| http://purl.uniprot.org/citations/12169691 | http://purl.uniprot.org/core/author | "Cohen H.T."xsd:string |
| http://purl.uniprot.org/citations/12169691 | http://purl.uniprot.org/core/author | "Cohen H.T."xsd:string |
| http://purl.uniprot.org/citations/12169691 | http://purl.uniprot.org/core/author | "Zhou M.I."xsd:string |
| http://purl.uniprot.org/citations/12169691 | http://purl.uniprot.org/core/author | "Zhou M.I."xsd:string |
| http://purl.uniprot.org/citations/12169691 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12169691 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12169691 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12169691 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12169691 | http://purl.uniprot.org/core/pages | "39887-39898"xsd:string |
| http://purl.uniprot.org/citations/12169691 | http://purl.uniprot.org/core/pages | "39887-39898"xsd:string |
| http://purl.uniprot.org/citations/12169691 | http://purl.uniprot.org/core/title | "The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1."xsd:string |
| http://purl.uniprot.org/citations/12169691 | http://purl.uniprot.org/core/title | "The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1."xsd:string |