| http://purl.uniprot.org/citations/12172552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12172552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12172552 | http://www.w3.org/2000/01/rdf-schema#comment | "The Rho family GTPases Rac, Rho and Cdc42 are critical in regulating the actin-based cytoskeleton, cell migration, growth, survival and gene expression. These GTPases are activated by guanine nucleotide-exchange factors (GEFs). A biochemical search for Cdc42 activators led to the cloning of zizimin1, a new protein whose overexpression induces Cdc42 activation. Sequence comparison combined with mutational analysis identified a new domain, which we named CZH2, that mediates direct interaction with Cdc42. CZH2-containing proteins constitute a new superfamily that includes the so-called 'CDM' proteins that bind to and activate Rac. Together, the results suggest that CZH2 is a new GEF domain for the Rho family of proteins."xsd:string |
| http://purl.uniprot.org/citations/12172552 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb835"xsd:string |
| http://purl.uniprot.org/citations/12172552 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb835"xsd:string |
| http://purl.uniprot.org/citations/12172552 | http://purl.uniprot.org/core/author | "Schwartz M.A."xsd:string |
| http://purl.uniprot.org/citations/12172552 | http://purl.uniprot.org/core/author | "Schwartz M.A."xsd:string |
| http://purl.uniprot.org/citations/12172552 | http://purl.uniprot.org/core/author | "Del Pozo M.A."xsd:string |
| http://purl.uniprot.org/citations/12172552 | http://purl.uniprot.org/core/author | "Del Pozo M.A."xsd:string |
| http://purl.uniprot.org/citations/12172552 | http://purl.uniprot.org/core/author | "Irani-Tehrani M."xsd:string |
| http://purl.uniprot.org/citations/12172552 | http://purl.uniprot.org/core/author | "Irani-Tehrani M."xsd:string |
| http://purl.uniprot.org/citations/12172552 | http://purl.uniprot.org/core/author | "Kiosses W.B."xsd:string |
| http://purl.uniprot.org/citations/12172552 | http://purl.uniprot.org/core/author | "Kiosses W.B."xsd:string |
| http://purl.uniprot.org/citations/12172552 | http://purl.uniprot.org/core/author | "Meller N."xsd:string |
| http://purl.uniprot.org/citations/12172552 | http://purl.uniprot.org/core/author | "Meller N."xsd:string |
| http://purl.uniprot.org/citations/12172552 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12172552 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12172552 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/12172552 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/12172552 | http://purl.uniprot.org/core/pages | "639-647"xsd:string |
| http://purl.uniprot.org/citations/12172552 | http://purl.uniprot.org/core/pages | "639-647"xsd:string |
| http://purl.uniprot.org/citations/12172552 | http://purl.uniprot.org/core/title | "Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins."xsd:string |
| http://purl.uniprot.org/citations/12172552 | http://purl.uniprot.org/core/title | "Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins."xsd:string |
| http://purl.uniprot.org/citations/12172552 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/12172552 | http://purl.uniprot.org/core/volume | "4"xsd:string |