| http://purl.uniprot.org/citations/12173935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12173935 | http://www.w3.org/2000/01/rdf-schema#comment | "Angiogenin and ribonuclease A share 33% sequence identity but have distinct functions. Angiogenin is a potent inducer of angiogenesis that is only weakly ribonucleolytic, whereas ribonuclease A is a robust ribonuclease that is not angiogenic. A chimera ("ARH-I"), in which angiogenin residues 58-70 are replaced with residues 59-73 of ribonuclease A, has intermediate ribonucleolytic potency and no angiogenic activity. Here we report a crystal structure of ARH-I that reveals the molecular basis for these characteristics. The ribonuclease A-derived (guest) segment adopts a structure largely similar to that in ribonuclease A, and successfully converts this region from a cell-binding site to a purine-binding site. At the same time, its presence causes complex changes in the angiogenin-derived (host) portion that account for much of the increased ribonuclease activity of ARH-I. Guest-host interactions of this type probably occur more generally in protein chimeras, emphasizing the importance of direct structural information for understanding the functional behavior of such molecules."xsd:string |
| http://purl.uniprot.org/citations/12173935 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi026151r"xsd:string |
| http://purl.uniprot.org/citations/12173935 | http://purl.uniprot.org/core/author | "Acharya K.R."xsd:string |
| http://purl.uniprot.org/citations/12173935 | http://purl.uniprot.org/core/author | "Holloway D.E."xsd:string |
| http://purl.uniprot.org/citations/12173935 | http://purl.uniprot.org/core/author | "Shapiro R."xsd:string |
| http://purl.uniprot.org/citations/12173935 | http://purl.uniprot.org/core/author | "Hares M.C."xsd:string |
| http://purl.uniprot.org/citations/12173935 | http://purl.uniprot.org/core/author | "Leonidas D.D."xsd:string |
| http://purl.uniprot.org/citations/12173935 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12173935 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/12173935 | http://purl.uniprot.org/core/pages | "10482-10489"xsd:string |
| http://purl.uniprot.org/citations/12173935 | http://purl.uniprot.org/core/title | "Guest-host crosstalk in an angiogenin-RNase A chimeric protein."xsd:string |
| http://purl.uniprot.org/citations/12173935 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/12173935 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12173935 |
| http://purl.uniprot.org/citations/12173935 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12173935 |
| http://purl.uniprot.org/uniprot/#_P61823-mappedCitation-12173935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12173935 |
| http://purl.uniprot.org/uniprot/#_P03950-mappedCitation-12173935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12173935 |
| http://purl.uniprot.org/uniprot/P03950 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12173935 |
| http://purl.uniprot.org/uniprot/P61823 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12173935 |