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| http://purl.uniprot.org/citations/12176032 | http://www.w3.org/2000/01/rdf-schema#comment | "The 14-3-3 protein family plays critical regulatory roles in signaling pathways in cell division and apoptosis. 14-3-3gamma is mainly expressed in brain. Using primary cultures of cerebral cortical astrocytes, we investigated the relationships between 14-3-3gamma proteins and actin in astrocytes in cell division and under ischemia. Our results showed that endogenous 14-3-3gamma proteins in immature astrocytes appeared filamentous and co-localized with filamentous actin (F-actin). During certain stages of mitosis, 14-3-3gamma proteins first aggregated and then formed a ring-like structure that surrounded the daughter nuclei and enclosed the F-actin. In 4-week-old cultures of astrocytes, 14-3-3gamma proteins appeared as punctate aggregates in the cytoplasm. Under ischemia, 14-3-3gamma proteins formed filamentous structures and were closely associated with F-actin in surviving astrocytes. However, in apoptotic astrocytes, the intensity of immunostaining of 14-3-3gamma proteins in the cytoplasm decreased. The proteins aggregated around the nucleus and dissociated from the actin filaments. Reciprocal co-immunoprecipitations demonstrated that endogenous 14-3-3gamma proteins bound to detergent-soluble actin and the level of binding increased after 4h of ischemia. As actin is a critical structural protein heavily involved in cell division and apoptotic death, our findings suggest that 14-3-3gamma proteins play a role in cytoskeletal function during the process of cell division and apoptosis in astrocytes in association with actin."xsd:string |
| http://purl.uniprot.org/citations/12176032 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(02)00895-1"xsd:string |
| http://purl.uniprot.org/citations/12176032 | http://purl.uniprot.org/core/author | "Chen X.Q."xsd:string |
| http://purl.uniprot.org/citations/12176032 | http://purl.uniprot.org/core/author | "Yu A.C."xsd:string |
| http://purl.uniprot.org/citations/12176032 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12176032 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/12176032 | http://purl.uniprot.org/core/pages | "657-663"xsd:string |
| http://purl.uniprot.org/citations/12176032 | http://purl.uniprot.org/core/title | "The association of 14-3-3gamma and actin plays a role in cell division and apoptosis in astrocytes."xsd:string |
| http://purl.uniprot.org/citations/12176032 | http://purl.uniprot.org/core/volume | "296"xsd:string |
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