| http://purl.uniprot.org/citations/12176037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12176037 | http://www.w3.org/2000/01/rdf-schema#comment | "A profile-based search of the SWISS-PROT database reveals that most protein tyrosine phosphatases (PTPs) contain at least one caveolin-1-binding motif. To ascertain if the presence of caveolin-binding motif(s) in PTPs corresponds to their actual localization in caveolin-1-enriched membrane fractions, we performed subcellular fractionating experiments. We found that all tested PTPs (PTP1B, PTP1C, SHPTP2, PTEN, and LAR) are actually localized in caveolin-enriched membrane fractions, despite their distribution in other subcellular sites, too. More than 1/2 of LAR and about 1/4 of SHPTP2 and PTP-1C are localized in caveolin-enriched membrane fractions whereas, in these fractions, PTP-1B and PTEN are poorly concentrated. Co-immunoprecipitation experiments with antibodies specific for each tested PTP demonstrated that all five phosphatases form molecular complexes with caveolin-1 in vivo. Collectively, our findings propose that particular PTPs could perform some of their cellular actions or are regulated by recruitment into caveolin-enriched membrane fractions."xsd:string |
| http://purl.uniprot.org/citations/12176037 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(02)00928-2"xsd:string |
| http://purl.uniprot.org/citations/12176037 | http://purl.uniprot.org/core/author | "Manao G."xsd:string |
| http://purl.uniprot.org/citations/12176037 | http://purl.uniprot.org/core/author | "Camici G."xsd:string |
| http://purl.uniprot.org/citations/12176037 | http://purl.uniprot.org/core/author | "Ramponi G."xsd:string |
| http://purl.uniprot.org/citations/12176037 | http://purl.uniprot.org/core/author | "Mazzinghi B."xsd:string |
| http://purl.uniprot.org/citations/12176037 | http://purl.uniprot.org/core/author | "Caselli A."xsd:string |
| http://purl.uniprot.org/citations/12176037 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12176037 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/12176037 | http://purl.uniprot.org/core/pages | "692-697"xsd:string |
| http://purl.uniprot.org/citations/12176037 | http://purl.uniprot.org/core/title | "Some protein tyrosine phosphatases target in part to lipid rafts and interact with caveolin-1."xsd:string |
| http://purl.uniprot.org/citations/12176037 | http://purl.uniprot.org/core/volume | "296"xsd:string |
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