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Purpose

To assess whether interactions of common alleles of two folate genes contribute to spina bifida risk.

Methods

Case-control study, comparing 203 children with spina bifida to 583 controls.

Results

Homozygosity for the 677C-T allele of 5,10-methylenetetrahydrofolate reductase (MTHFR) alone was associated with an odds ratio for spina bifida of 1.57 (95% confidence interval [CI], 1.02-2.38). For the 844ins68 allele of cystathionine-beta-synthase alone, the odds ratio was 0.83 (95% CI, 0.39-1.64). For the joint genotype, the odds ratio was 3.69 (95% CI, 1.04-13.50).

Conclusions

Interactions between common alleles of folate genes might contribute to the risk for spina bifida."xsd:string
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http://purl.uniprot.org/citations/12180146http://purl.uniprot.org/core/author"Iolascon A."xsd:string
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http://purl.uniprot.org/citations/12180146http://purl.uniprot.org/core/author"Botto L.D."xsd:string
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http://purl.uniprot.org/citations/12180146http://purl.uniprot.org/core/pages"126-130"xsd:string
http://purl.uniprot.org/citations/12180146http://purl.uniprot.org/core/title"Spina bifida and folate-related genes: a study of gene-gene interactions."xsd:string
http://purl.uniprot.org/citations/12180146http://purl.uniprot.org/core/volume"4"xsd:string
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