| http://purl.uniprot.org/citations/12181749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12181749 | http://www.w3.org/2000/01/rdf-schema#comment | "Interferons enhance the cellular antiviral response by inducing expression of protective proteins. Many of these proteins are activated by dsRNA, a typical by-product of viral infection. Here we show that type-I and type-II interferons can sensitize cells to dsRNA-induced cytotoxicity. In caspase-8- or FADD-deficient Jurkat cells dsRNA induces necrosis, instead of apoptosis. In L929sA cells dsRNA-induced necrosis involves high reactive oxygen species production. The antioxidant butylated hydroxyanisole protects cells from necrosis, but shifts the response to apoptosis. Treatment with the caspase inhibitor benzyloxycarbonyl-Val-Ala-DL-Asp(OMe)-fluoromethylketone or overexpression of Bcl-2 prevent this shift and promote necrosis. Our results suggest that a single stimulus can initiate different death-signaling pathways, leading to either necrotic or apoptotic cell death. Inhibition of key events in these signaling pathways, such as caspase activation, cytochrome c release or mitochondrial reactive oxygen species production, tips the balance between necrosis and apoptosis, leading to dominance of one of these death programs."xsd:string |
| http://purl.uniprot.org/citations/12181749 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.cdd.4401051"xsd:string |
| http://purl.uniprot.org/citations/12181749 | http://purl.uniprot.org/core/author | "Saelens X."xsd:string |
| http://purl.uniprot.org/citations/12181749 | http://purl.uniprot.org/core/author | "Vandenabeele P."xsd:string |
| http://purl.uniprot.org/citations/12181749 | http://purl.uniprot.org/core/author | "Vanden Berghe T."xsd:string |
| http://purl.uniprot.org/citations/12181749 | http://purl.uniprot.org/core/author | "Kalai M."xsd:string |
| http://purl.uniprot.org/citations/12181749 | http://purl.uniprot.org/core/author | "Meeus A."xsd:string |
| http://purl.uniprot.org/citations/12181749 | http://purl.uniprot.org/core/author | "Van Loo G."xsd:string |
| http://purl.uniprot.org/citations/12181749 | http://purl.uniprot.org/core/author | "Burm W."xsd:string |
| http://purl.uniprot.org/citations/12181749 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12181749 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/12181749 | http://purl.uniprot.org/core/pages | "981-994"xsd:string |
| http://purl.uniprot.org/citations/12181749 | http://purl.uniprot.org/core/title | "Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA."xsd:string |
| http://purl.uniprot.org/citations/12181749 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/12181749 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12181749 |
| http://purl.uniprot.org/citations/12181749 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12181749 |
| http://purl.uniprot.org/uniprot/#_Q13158-mappedCitation-12181749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12181749 |
| http://purl.uniprot.org/uniprot/#_Q14790-mappedCitation-12181749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12181749 |
| http://purl.uniprot.org/uniprot/#_O00206-mappedCitation-12181749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12181749 |
| http://purl.uniprot.org/uniprot/#_Q13546-mappedCitation-12181749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12181749 |
| http://purl.uniprot.org/uniprot/#_P08571-mappedCitation-12181749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12181749 |
| http://purl.uniprot.org/uniprot/#_Q86XR7-mappedCitation-12181749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12181749 |
| http://purl.uniprot.org/uniprot/#_O15455-mappedCitation-12181749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12181749 |
| http://purl.uniprot.org/uniprot/#_Q8IUC6-mappedCitation-12181749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12181749 |