| http://purl.uniprot.org/citations/12183361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12183361 | http://www.w3.org/2000/01/rdf-schema#comment | "beta-catenin and plakoglobin (gamma-catenin) are homologous molecules involved in cell adhesion, linking cadherin receptors to the cytoskeleton. beta-catenin is also a key component of the Wnt pathway by being a coactivator of LEF/TCF transcription factors. To identify novel target genes induced by beta-catenin and/or plakoglobin, DNA microarray analysis was carried out with RNA from cells overexpressing either protein. This analysis revealed that Nr-CAM is the gene most extensively induced by both catenins. Overexpression of either beta-catenin or plakoglobin induced Nr-CAM in a variety of cell types and the LEF/TCF binding sites in the Nr-CAM promoter were required for its activation by catenins. Retroviral transduction of Nr-CAM into NIH3T3 cells stimulated cell growth, enhanced motility, induced transformation, and produced rapidly growing tumors in nude mice. Nr-CAM and LEF-1 expression was elevated in human colon cancer tissue and cell lines and in human malignant melanoma cell lines but not in melanocytes or normal colon tissue. Dominant negative LEF-1 decreased Nr-CAM expression and antibodies to Nr-CAM inhibited the motility of B16 melanoma cells. The results indicate that induction of Nr-CAM transcription by beta-catenin or plakoglobin plays a role in melanoma and colon cancer tumorigenesis, probably by promoting cell growth and motility."xsd:string |
| http://purl.uniprot.org/citations/12183361 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.227502"xsd:string |
| http://purl.uniprot.org/citations/12183361 | http://purl.uniprot.org/core/author | "Ben-Ze'ev A."xsd:string |
| http://purl.uniprot.org/citations/12183361 | http://purl.uniprot.org/core/author | "Feinstein E."xsd:string |
| http://purl.uniprot.org/citations/12183361 | http://purl.uniprot.org/core/author | "Einat P."xsd:string |
| http://purl.uniprot.org/citations/12183361 | http://purl.uniprot.org/core/author | "Shtutman M."xsd:string |
| http://purl.uniprot.org/citations/12183361 | http://purl.uniprot.org/core/author | "Ben-Yedidia T."xsd:string |
| http://purl.uniprot.org/citations/12183361 | http://purl.uniprot.org/core/author | "Conacci-Sorrell M.E."xsd:string |
| http://purl.uniprot.org/citations/12183361 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12183361 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/12183361 | http://purl.uniprot.org/core/pages | "2058-2072"xsd:string |
| http://purl.uniprot.org/citations/12183361 | http://purl.uniprot.org/core/title | "Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/12183361 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/12183361 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12183361 |
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