| http://purl.uniprot.org/citations/12183628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12183628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12183628 | http://www.w3.org/2000/01/rdf-schema#comment | "C-1027 is a potent antitumor agent with a previously undescribed molecular architecture and mode of action. Cloning and characterization of the 85-kilobase C-1027 biosynthesis gene cluster from Streptomyces globisporus revealed (i) an iterative type I polyketide synthase that is distinct from any bacterial polyketide synthases known to date, (ii) a general polyketide pathway for the biosynthesis of both the 9- and 10-membered enediyne antibiotics, and (iii) a convergent biosynthetic strategy for the C-1027 chromophore from four building blocks. Manipulation of genes governing C-1027 biosynthesis allowed us to produce an enediyne compound in a predicted manner."xsd:string |
| http://purl.uniprot.org/citations/12183628 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1072110"xsd:string |
| http://purl.uniprot.org/citations/12183628 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1072110"xsd:string |
| http://purl.uniprot.org/citations/12183628 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/12183628 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/12183628 | http://purl.uniprot.org/core/author | "Shen B."xsd:string |
| http://purl.uniprot.org/citations/12183628 | http://purl.uniprot.org/core/author | "Shen B."xsd:string |
| http://purl.uniprot.org/citations/12183628 | http://purl.uniprot.org/core/author | "Standage S."xsd:string |
| http://purl.uniprot.org/citations/12183628 | http://purl.uniprot.org/core/author | "Standage S."xsd:string |
| http://purl.uniprot.org/citations/12183628 | http://purl.uniprot.org/core/author | "Christenson S.D."xsd:string |
| http://purl.uniprot.org/citations/12183628 | http://purl.uniprot.org/core/author | "Christenson S.D."xsd:string |
| http://purl.uniprot.org/citations/12183628 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12183628 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12183628 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/12183628 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/12183628 | http://purl.uniprot.org/core/pages | "1170-1173"xsd:string |
| http://purl.uniprot.org/citations/12183628 | http://purl.uniprot.org/core/pages | "1170-1173"xsd:string |
| http://purl.uniprot.org/citations/12183628 | http://purl.uniprot.org/core/title | "Biosynthesis of the enediyne antitumor antibiotic C-1027."xsd:string |
| http://purl.uniprot.org/citations/12183628 | http://purl.uniprot.org/core/title | "Biosynthesis of the enediyne antitumor antibiotic C-1027."xsd:string |
| http://purl.uniprot.org/citations/12183628 | http://purl.uniprot.org/core/volume | "297"xsd:string |
| http://purl.uniprot.org/citations/12183628 | http://purl.uniprot.org/core/volume | "297"xsd:string |
| http://purl.uniprot.org/citations/12183628 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12183628 |
| http://purl.uniprot.org/citations/12183628 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12183628 |