| http://purl.uniprot.org/citations/12183632 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12183632 | http://www.w3.org/2000/01/rdf-schema#comment | "Matrix metalloproteinases (MMPs) are implicated in the pathogenesis of neurodegenerative diseases and stroke. However, the mechanism of MMP activation remains unclear. We report that MMP activation involves S-nitrosylation. During cerebral ischemia in vivo, MMP-9 colocalized with neuronal nitric oxide synthase. S-Nitrosylation activated MMP-9 in vitro and induced neuronal apoptosis. Mass spectrometry identified the active derivative of MMP-9, both in vitro and in vivo, as a stable sulfinic or sulfonic acid, whose formation was triggered by S-nitrosylation. These findings suggest a potential extracellular proteolysis pathway to neuronal cell death in which S-nitrosylation activates MMPs, and further oxidation results in a stable posttranslational modification with pathological activity."xsd:string |
| http://purl.uniprot.org/citations/12183632 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1073634"xsd:string |
| http://purl.uniprot.org/citations/12183632 | http://purl.uniprot.org/core/author | "Gu Z."xsd:string |
| http://purl.uniprot.org/citations/12183632 | http://purl.uniprot.org/core/author | "Liddington R.C."xsd:string |
| http://purl.uniprot.org/citations/12183632 | http://purl.uniprot.org/core/author | "Yan B."xsd:string |
| http://purl.uniprot.org/citations/12183632 | http://purl.uniprot.org/core/author | "Cui J."xsd:string |
| http://purl.uniprot.org/citations/12183632 | http://purl.uniprot.org/core/author | "Smith J.W."xsd:string |
| http://purl.uniprot.org/citations/12183632 | http://purl.uniprot.org/core/author | "Strongin A."xsd:string |
| http://purl.uniprot.org/citations/12183632 | http://purl.uniprot.org/core/author | "Lipton S.A."xsd:string |
| http://purl.uniprot.org/citations/12183632 | http://purl.uniprot.org/core/author | "Kridel S.J."xsd:string |
| http://purl.uniprot.org/citations/12183632 | http://purl.uniprot.org/core/author | "Kaul M."xsd:string |
| http://purl.uniprot.org/citations/12183632 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12183632 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/12183632 | http://purl.uniprot.org/core/pages | "1186-1190"xsd:string |
| http://purl.uniprot.org/citations/12183632 | http://purl.uniprot.org/core/title | "S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death."xsd:string |
| http://purl.uniprot.org/citations/12183632 | http://purl.uniprot.org/core/volume | "297"xsd:string |
| http://purl.uniprot.org/citations/12183632 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12183632 |
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