| http://purl.uniprot.org/citations/12186849 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12186849 | http://www.w3.org/2000/01/rdf-schema#comment | "The unfolded protein response (UPR) counteracts stress caused by unprocessed ER client proteins. A genome-wide survey showed impaired induction of many UPR target genes in xbp-1 mutant Caenorhabditis elegans that are unable to signal in the highly conserved IRE1-dependent UPR pathway. However a family of genes, abu (activated in blocked UPR), was induced to higher levels in ER-stressed xbp-1 mutant animals than in ER-stressed wild-type animals. RNA-mediated interference (RNAi) inactivation of a representative abu family member, abu-1 (AC3.3), activated the ER stress marker hsp-4::gfp in otherwise normal animals and killed 50% of ER-stressed ire-1 and xbp-1 mutant animals. Abu-1(RNAi) also enhanced the effect of inactivation of sel-1, an ER-associated protein degradation gene. The nine abu genes encode highly related type I transmembrane proteins whose lumenal domains have sequence similarity to a mammalian cell surface scavenger receptor of endothelial cells that binds chemically modified extracellular proteins and directs their lysosomal degradation. Our findings that ABU-1 is an intracellular protein located within the endomembrane system that is induced by ER stress in xbp-1 mutant animals suggest that ABU proteins may interact with abnormal ER client proteins and this function may be particularly important in animals with an impaired UPR."xsd:string |
| http://purl.uniprot.org/citations/12186849 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200203086"xsd:string |
| http://purl.uniprot.org/citations/12186849 | http://purl.uniprot.org/core/author | "Yoneda T."xsd:string |
| http://purl.uniprot.org/citations/12186849 | http://purl.uniprot.org/core/author | "Ron D."xsd:string |
| http://purl.uniprot.org/citations/12186849 | http://purl.uniprot.org/core/author | "Clark S.G."xsd:string |
| http://purl.uniprot.org/citations/12186849 | http://purl.uniprot.org/core/author | "Yun C."xsd:string |
| http://purl.uniprot.org/citations/12186849 | http://purl.uniprot.org/core/author | "Calfon M."xsd:string |
| http://purl.uniprot.org/citations/12186849 | http://purl.uniprot.org/core/author | "Urano F."xsd:string |
| http://purl.uniprot.org/citations/12186849 | http://purl.uniprot.org/core/author | "Kiraly M."xsd:string |
| http://purl.uniprot.org/citations/12186849 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12186849 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/12186849 | http://purl.uniprot.org/core/pages | "639-646"xsd:string |
| http://purl.uniprot.org/citations/12186849 | http://purl.uniprot.org/core/title | "A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response."xsd:string |
| http://purl.uniprot.org/citations/12186849 | http://purl.uniprot.org/core/volume | "158"xsd:string |
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