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| http://purl.uniprot.org/citations/12189243 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-12 is considered a critical proinflammatory cytokine for autoimmune diseases such as multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). IL-12 is a heterodimer composed of a p35 subunit and a common p40 subunit shared by other cytokines. Both IL-12 p40(-/-) and p35(-/-) mice fail to produce IL-12 p70 heterodimer. However, in contrast to p40(-/-) mice, p35(-/-) mice are highly susceptible to the induction of EAE, establishing that IL-12 p70 is not essential for the development of EAE. When compared with wild-type mice, both p40(-/-) and p35(-/-) mice show deficiencies in primary IFN-gamma responses by lymph node cells. Expression profiling of the inflamed CNS revealed that Th2 cytokines such as IL-4 and IL-10 are upregulated in p35(-/-) mice, whereas LT-alpha and TNF-alpha levels are reduced. These studies show that a molecule other than IL-12 p70, which uses the p40 subunit, fulfills the functions previously attributed to IL-12 with regard to the development and pathogenesis of this autoimmune disease."xsd:string |
| http://purl.uniprot.org/citations/12189243 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci15751"xsd:string |
| http://purl.uniprot.org/citations/12189243 | http://purl.uniprot.org/core/author | "Becher B."xsd:string |
| http://purl.uniprot.org/citations/12189243 | http://purl.uniprot.org/core/author | "Noelle R.J."xsd:string |
| http://purl.uniprot.org/citations/12189243 | http://purl.uniprot.org/core/author | "Durell B.G."xsd:string |
| http://purl.uniprot.org/citations/12189243 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12189243 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/12189243 | http://purl.uniprot.org/core/pages | "493-497"xsd:string |
| http://purl.uniprot.org/citations/12189243 | http://purl.uniprot.org/core/title | "Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12."xsd:string |
| http://purl.uniprot.org/citations/12189243 | http://purl.uniprot.org/core/volume | "110"xsd:string |
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