| http://purl.uniprot.org/citations/12189588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12189588 | http://www.w3.org/2000/01/rdf-schema#comment | "Metabolic syndrome is characterized by a clustering of metabolic abnormalities: insulin resistance - hyperinsulinemia, dyslipidemia (high triglycerides and low HDL - cholesterol serum concentrations), impaired glucose tolerance and/or type 2 diabetes, and hypertension. The aim of this study was to analyse the role of different variables of metabolic syndrome, including leptin, in 74 non-obese children and 68 children with non-syndromal obesity. As metabolic syndrome variables, we have included body mass index, waist circumference, trunk-to-total skinfolds (%), systolic blood pressure, diastolic blood pressure, glucose, uric acid, fasting insulin, triglycerides and high-density lipoprotein-cholesterol (HDL-C). Factor analysis showed 4 factors in each group. In non-obese children, waist circumference, BMI, fasting insulin, triglycerides, trunk-to-total skinfolds (%), leptin and uric acid loaded positively on factor 1, and HDL-C loaded negatively on this factor; systolic and diastolic blood pressure had high positive loadings in factor 2; HDL-C and leptin showed positive loadings and triglycerides and uric acid, negative loadings in factor 3; and, finally, glucose and insulin showed positive loadings in factor 4. These four factors explained 72.16 % of the total variance in the non-obese group. In obese children, BMI, waist circumference, leptin, diastolic blood pressure and systolic blood pressure loaded positively on factor 1; diastolic blood pressure, trunk-to-total skinfolds (%), uric acid and systolic blood pressure showed high positive loadings in factor 2; fasting insulin, glucose and triglycerides showed positive loadings in factor 3; and, finally, triglycerides showed positive loadings and HDL-C negative loadings in factor 4. These four factors explained 74.18 % of the total variance in the obese group. Our results point to a different homeostatic control of metabolic syndrome characteristics in obese and non-obese children. Leptin seems to play a key underlying role in metabolic syndrome, especially in the obese group."xsd:string |
| http://purl.uniprot.org/citations/12189588 | http://purl.org/dc/terms/identifier | "doi:10.1055/s-2002-33472"xsd:string |
| http://purl.uniprot.org/citations/12189588 | http://purl.uniprot.org/core/author | "Bueno M."xsd:string |
| http://purl.uniprot.org/citations/12189588 | http://purl.uniprot.org/core/author | "Giner A."xsd:string |
| http://purl.uniprot.org/citations/12189588 | http://purl.uniprot.org/core/author | "Rodriguez G."xsd:string |
| http://purl.uniprot.org/citations/12189588 | http://purl.uniprot.org/core/author | "Fleta J."xsd:string |
| http://purl.uniprot.org/citations/12189588 | http://purl.uniprot.org/core/author | "Juste M.G."xsd:string |
| http://purl.uniprot.org/citations/12189588 | http://purl.uniprot.org/core/author | "Moreno L.A."xsd:string |
| http://purl.uniprot.org/citations/12189588 | http://purl.uniprot.org/core/author | "Pineda I."xsd:string |
| http://purl.uniprot.org/citations/12189588 | http://purl.uniprot.org/core/author | "Sarria A."xsd:string |
| http://purl.uniprot.org/citations/12189588 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12189588 | http://purl.uniprot.org/core/name | "Horm Metab Res"xsd:string |
| http://purl.uniprot.org/citations/12189588 | http://purl.uniprot.org/core/pages | "394-399"xsd:string |
| http://purl.uniprot.org/citations/12189588 | http://purl.uniprot.org/core/title | "Leptin and metabolic syndrome in obese and non-obese children."xsd:string |
| http://purl.uniprot.org/citations/12189588 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/12189588 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12189588 |
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