| http://purl.uniprot.org/citations/12191486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12191486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12191486 | http://www.w3.org/2000/01/rdf-schema#comment | "Generation of Interleukin (IL)-1beta via cleavage of its proform requires the activity of caspase-1 (and caspase-11 in mice), but the mechanism involved in the activation of the proinflammatory caspases remains elusive. Here we report the identification of a caspase-activating complex that we call the inflammasome. The inflammasome comprises caspase-1, caspase-5, Pycard/Asc, and NALP1, a Pyrin domain-containing protein sharing structural homology with NODs. Using a cell-free system, we show that proinflammatory caspase activation and proIL-1beta processing is lost upon prior immunodepletion of Pycard. Moreover, expression of a dominant-negative form of Pycard in differentiated THP-1 cells blocks proIL-1beta maturation and activation of inflammatory caspases induced by LPS in vivo. Thus, the inflammasome constitutes an important arm of the innate immunity."xsd:string |
| http://purl.uniprot.org/citations/12191486 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(02)00599-3"xsd:string |
| http://purl.uniprot.org/citations/12191486 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(02)00599-3"xsd:string |
| http://purl.uniprot.org/citations/12191486 | http://purl.uniprot.org/core/author | "Burns K."xsd:string |
| http://purl.uniprot.org/citations/12191486 | http://purl.uniprot.org/core/author | "Burns K."xsd:string |
| http://purl.uniprot.org/citations/12191486 | http://purl.uniprot.org/core/author | "Tschopp J."xsd:string |
| http://purl.uniprot.org/citations/12191486 | http://purl.uniprot.org/core/author | "Tschopp J."xsd:string |
| http://purl.uniprot.org/citations/12191486 | http://purl.uniprot.org/core/author | "Martinon F."xsd:string |
| http://purl.uniprot.org/citations/12191486 | http://purl.uniprot.org/core/author | "Martinon F."xsd:string |
| http://purl.uniprot.org/citations/12191486 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12191486 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12191486 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/12191486 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/12191486 | http://purl.uniprot.org/core/pages | "417-426"xsd:string |
| http://purl.uniprot.org/citations/12191486 | http://purl.uniprot.org/core/pages | "417-426"xsd:string |
| http://purl.uniprot.org/citations/12191486 | http://purl.uniprot.org/core/title | "The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta."xsd:string |
| http://purl.uniprot.org/citations/12191486 | http://purl.uniprot.org/core/title | "The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta."xsd:string |
| http://purl.uniprot.org/citations/12191486 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/12191486 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/12191486 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12191486 |
| http://purl.uniprot.org/citations/12191486 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12191486 |
| http://purl.uniprot.org/citations/12191486 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12191486 |
| http://purl.uniprot.org/citations/12191486 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12191486 |