| http://purl.uniprot.org/citations/12194852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12194852 | http://www.w3.org/2000/01/rdf-schema#comment | "Isoform-specific null mutations were used to define the functions of three orphan members of the nuclear receptor superfamily, E75A, E75B, and E75C, encoded by the E75 early ecdysteroid-inducible gene. E75B mutants are viable and fertile, while E75C mutants die as adults. In contrast, E75A mutants have a reduced ecdysteroid titer during larval development, resulting in developmental delays, developmental arrests, and molting defects. Remarkably, some E75A mutant second instar larvae display a heterochronic phenotype in which they induce genes specific to the third instar and pupariate without undergoing a molt. We propose that ecdysteroid-induced E75A expression defines a feed-forward pathway that amplifies or maintains the ecdysteroid titer during larval development, ensuring proper temporal progression through the life cycle."xsd:string |
| http://purl.uniprot.org/citations/12194852 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1534-5807(02)00204-6"xsd:string |
| http://purl.uniprot.org/citations/12194852 | http://purl.uniprot.org/core/author | "Thummel C.S."xsd:string |
| http://purl.uniprot.org/citations/12194852 | http://purl.uniprot.org/core/author | "Segraves W.A."xsd:string |
| http://purl.uniprot.org/citations/12194852 | http://purl.uniprot.org/core/author | "Bialecki M."xsd:string |
| http://purl.uniprot.org/citations/12194852 | http://purl.uniprot.org/core/author | "Fichtenberg C."xsd:string |
| http://purl.uniprot.org/citations/12194852 | http://purl.uniprot.org/core/author | "Shilton A."xsd:string |
| http://purl.uniprot.org/citations/12194852 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12194852 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/12194852 | http://purl.uniprot.org/core/pages | "209-220"xsd:string |
| http://purl.uniprot.org/citations/12194852 | http://purl.uniprot.org/core/title | "Loss of the ecdysteroid-inducible E75A orphan nuclear receptor uncouples molting from metamorphosis in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/12194852 | http://purl.uniprot.org/core/volume | "3"xsd:string |
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