| http://purl.uniprot.org/citations/12194869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12194869 | http://www.w3.org/2000/01/rdf-schema#comment | "Cell survival is determined by a balance among signaling cascades, including those that recruit the Akt and JNK pathways. Here we describe a novel interaction between Akt1 and JNK interacting protein 1 (JIP1), a JNK pathway scaffold. Direct association between Akt1 and JIP1 was observed in primary neurons. Neuronal exposure to an excitotoxic stimulus decreased the Akt1-JIP1 interaction and concomitantly increased association between JIP1 and JNK. Akt1 interaction with JIP1 inhibited JIP1-mediated potentiation of JNK activity by decreasing JIP1 binding to specific JNK pathway kinases. Consistent with this view, neurons from Akt1-deficient mice exhibited higher susceptibility to kainate than wild-type littermates. Overexpression of Akt1 mutants that bind JIP1 reduced excitotoxic apoptosis. These results suggest that Akt1 binding to JIP1 acts as a regulatory gate preventing JNK activation, which is released under conditions of excitotoxic injury."xsd:string |
| http://purl.uniprot.org/citations/12194869 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(02)00821-8"xsd:string |
| http://purl.uniprot.org/citations/12194869 | http://purl.uniprot.org/core/author | "Meyer D."xsd:string |
| http://purl.uniprot.org/citations/12194869 | http://purl.uniprot.org/core/author | "Birnbaum M.J."xsd:string |
| http://purl.uniprot.org/citations/12194869 | http://purl.uniprot.org/core/author | "Margolis B."xsd:string |
| http://purl.uniprot.org/citations/12194869 | http://purl.uniprot.org/core/author | "Yano H."xsd:string |
| http://purl.uniprot.org/citations/12194869 | http://purl.uniprot.org/core/author | "Cho H."xsd:string |
| http://purl.uniprot.org/citations/12194869 | http://purl.uniprot.org/core/author | "Chao M.V."xsd:string |
| http://purl.uniprot.org/citations/12194869 | http://purl.uniprot.org/core/author | "Kim A.H."xsd:string |
| http://purl.uniprot.org/citations/12194869 | http://purl.uniprot.org/core/author | "Monks B."xsd:string |
| http://purl.uniprot.org/citations/12194869 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12194869 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/12194869 | http://purl.uniprot.org/core/pages | "697-709"xsd:string |
| http://purl.uniprot.org/citations/12194869 | http://purl.uniprot.org/core/title | "Akt1 regulates a JNK scaffold during excitotoxic apoptosis."xsd:string |
| http://purl.uniprot.org/citations/12194869 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/12194869 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12194869 |
| http://purl.uniprot.org/citations/12194869 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12194869 |
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| http://purl.uniprot.org/uniprot/#_A0A8I6ABA5-mappedCitation-12194869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12194869 |
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| http://purl.uniprot.org/uniprot/#_P47196-mappedCitation-12194869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12194869 |