| http://purl.uniprot.org/citations/12196287 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12196287 | http://www.w3.org/2000/01/rdf-schema#comment | "Immunological synapse assembly relies on the clustering of lipid rafts and is required for optimal T cell activation. We demonstrate that the Wiskott-Aldrich syndrome protein (WASP) is recruited to lipid rafts immediately after TCR and CD28 triggering and is required for the movements of lipid rafts. T cells from Wiskott-Aldrich syndrome (WAS) patients, lacking WASP, proliferate poorly after TCR/CD28 activation and have impaired capacities to cluster the lipid raft marker GM1 and to upregulate GM1 cell surface expression. T cell proliferation and lipid raft clustering are restored by retroviral transfer of the WASP gene. These results demonstrate that WASP plays a central role in the movements of lipid rafts and identify a potential mechanism underlying the T cell defect affecting WAS patients."xsd:string |
| http://purl.uniprot.org/citations/12196287 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1074-7613(02)00360-6"xsd:string |
| http://purl.uniprot.org/citations/12196287 | http://purl.uniprot.org/core/author | "Aiuti A."xsd:string |
| http://purl.uniprot.org/citations/12196287 | http://purl.uniprot.org/core/author | "Martino S."xsd:string |
| http://purl.uniprot.org/citations/12196287 | http://purl.uniprot.org/core/author | "Roncarolo M.G."xsd:string |
| http://purl.uniprot.org/citations/12196287 | http://purl.uniprot.org/core/author | "Dupre L."xsd:string |
| http://purl.uniprot.org/citations/12196287 | http://purl.uniprot.org/core/author | "Bordignon C."xsd:string |
| http://purl.uniprot.org/citations/12196287 | http://purl.uniprot.org/core/author | "Saracco P."xsd:string |
| http://purl.uniprot.org/citations/12196287 | http://purl.uniprot.org/core/author | "Trifari S."xsd:string |
| http://purl.uniprot.org/citations/12196287 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12196287 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/12196287 | http://purl.uniprot.org/core/pages | "157-166"xsd:string |
| http://purl.uniprot.org/citations/12196287 | http://purl.uniprot.org/core/title | "Wiskott-Aldrich syndrome protein regulates lipid raft dynamics during immunological synapse formation."xsd:string |
| http://purl.uniprot.org/citations/12196287 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/12196287 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12196287 |
| http://purl.uniprot.org/citations/12196287 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12196287 |
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| http://purl.uniprot.org/uniprot/#_P42768-mappedCitation-12196287 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12196287 |
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| http://purl.uniprot.org/uniprot/P42768 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12196287 |
| http://purl.uniprot.org/uniprot/Q2PAL5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12196287 |
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