| http://purl.uniprot.org/citations/12197885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12197885 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-10 (IL-10) is a major regulatory cytokine of inflammatory responses that is considered to play an important role in specific immunotherapy. However, whether IL-10 enhances or inhibits B-cell IgE production has remained a matter of contention. To clarify the effect of IL-10 on IgE synthesis in the presence of IL-4 and CD40 signalling, we examined B-cell proliferation, germline epsilon transcripts and plasma cell differentiation. In addition, the effect of CD27 signalling on IgE synthesis in the presence of IL-10, IL-4 and CD40 signalling was investigated. IL-10 facilitated the production of IgE in mononuclear cells and highly purified B-cells, enhanced B-cell proliferation and, most importantly, promoted the generation of plasma cells. However, IL-10 did not enhance expression of germline epsilon transcripts. The addition of CD27 signalling through the use of CD32-CD27 ligand (CD70) double transfectants significantly diminished the B-cell proliferation, IgE synthesis and plasma cell differentiation enhanced by IL-10. IL-10 enhances B-cell IgE production by promoting differentiation into plasma cells. CD27/CD70 interactions under IL-10 and sufficient CD40 cosignalling exert the opposite effect on IgE synthesis. The results of this study indicate that precautions are critical when planning immunotherapy using IL-10 in IgE-related allergic diseases."xsd:string |
| http://purl.uniprot.org/citations/12197885 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1365-2249.2002.01932.x"xsd:string |
| http://purl.uniprot.org/citations/12197885 | http://purl.uniprot.org/core/author | "Kobayashi N."xsd:string |
| http://purl.uniprot.org/citations/12197885 | http://purl.uniprot.org/core/author | "Agematsu K."xsd:string |
| http://purl.uniprot.org/citations/12197885 | http://purl.uniprot.org/core/author | "Nagumo H."xsd:string |
| http://purl.uniprot.org/citations/12197885 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12197885 | http://purl.uniprot.org/core/name | "Clin Exp Immunol"xsd:string |
| http://purl.uniprot.org/citations/12197885 | http://purl.uniprot.org/core/pages | "446-452"xsd:string |
| http://purl.uniprot.org/citations/12197885 | http://purl.uniprot.org/core/title | "IL-10 enhances B-cell IgE synthesis by promoting differentiation into plasma cells, a process that is inhibited by CD27/CD70 interaction."xsd:string |
| http://purl.uniprot.org/citations/12197885 | http://purl.uniprot.org/core/volume | "129"xsd:string |
| http://purl.uniprot.org/citations/12197885 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12197885 |
| http://purl.uniprot.org/citations/12197885 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12197885 |
| http://purl.uniprot.org/uniprot/#_A0A0U5JA32-mappedCitation-12197885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12197885 |
| http://purl.uniprot.org/uniprot/#_P26842-mappedCitation-12197885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12197885 |
| http://purl.uniprot.org/uniprot/#_P32970-mappedCitation-12197885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12197885 |
| http://purl.uniprot.org/uniprot/P32970 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12197885 |
| http://purl.uniprot.org/uniprot/P26842 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12197885 |
| http://purl.uniprot.org/uniprot/A0A0U5JA32 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12197885 |