| http://purl.uniprot.org/citations/12198175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12198175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12198175 | http://www.w3.org/2000/01/rdf-schema#comment | "Yeast mhr1-1 was isolated as a defective mutation in mitochondrial DNA (mtDNA) recombination. About half of mhr1-1 cells lose mtDNA during growth at a higher temperature. Here, we show that mhr1-1 exhibits a defect in the partitioning of nascent mtDNA into buds and is a base-substitution mutation in MHR1 encoding a mitochondrial matrix protein. We found that the Mhr1 protein (Mhr1p) has activity to pair single-stranded DNA and homologous double-stranded DNA to form heteroduplex joints in vitro, and that mhr1-1 causes the loss of this activity, indicating its role in homologous mtDNA recombination. While the majority of the mtDNA in the mother cells consists of head-to-tail concatemers, more than half of the mtDNA in the buds exists as genome-sized monomers. The mhr1-1 deltacce1 double mutant cells do not maintain any mtDNA, indicating the strict dependence of mtDNA maintenance on recombination functions. These results suggest a mechanism for mtDNA inheritance similar to that operating in the replication and packaging of phage DNA."xsd:string |
| http://purl.uniprot.org/citations/12198175 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdf466"xsd:string |
| http://purl.uniprot.org/citations/12198175 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdf466"xsd:string |
| http://purl.uniprot.org/citations/12198175 | http://purl.uniprot.org/core/author | "Shibata T."xsd:string |
| http://purl.uniprot.org/citations/12198175 | http://purl.uniprot.org/core/author | "Shibata T."xsd:string |
| http://purl.uniprot.org/citations/12198175 | http://purl.uniprot.org/core/author | "Ling F."xsd:string |
| http://purl.uniprot.org/citations/12198175 | http://purl.uniprot.org/core/author | "Ling F."xsd:string |
| http://purl.uniprot.org/citations/12198175 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12198175 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12198175 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/12198175 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/12198175 | http://purl.uniprot.org/core/pages | "4730-4740"xsd:string |
| http://purl.uniprot.org/citations/12198175 | http://purl.uniprot.org/core/pages | "4730-4740"xsd:string |
| http://purl.uniprot.org/citations/12198175 | http://purl.uniprot.org/core/title | "Recombination-dependent mtDNA partitioning: in vivo role of Mhr1p to promote pairing of homologous DNA."xsd:string |
| http://purl.uniprot.org/citations/12198175 | http://purl.uniprot.org/core/title | "Recombination-dependent mtDNA partitioning: in vivo role of Mhr1p to promote pairing of homologous DNA."xsd:string |
| http://purl.uniprot.org/citations/12198175 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/12198175 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/12198175 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12198175 |
| http://purl.uniprot.org/citations/12198175 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12198175 |
| http://purl.uniprot.org/citations/12198175 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12198175 |
| http://purl.uniprot.org/citations/12198175 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12198175 |
| http://purl.uniprot.org/uniprot/Q06630 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12198175 |
| http://purl.uniprot.org/uniprot/Q03702#attribution-EE4758530BC23FCB0408FDA9CF0CCD2A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12198175 |