| http://purl.uniprot.org/citations/12200127 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12200127 | http://www.w3.org/2000/01/rdf-schema#comment | "The involvement of phosphatidylinositol 3 (PI 3)-kinase in the signalling pathways leading to MMP-9 expression in glioma cells remains unclear. Here, we report that PI 3-kinase inhibits MMP-9 expression induced by either IL-1 or TNF-alpha in rat C6 glioma cells. Using zymography and semi-quantitative RT-PCR analysis, we showed that treatment of C6 cells with wortmannin, an inhibitor of PI 3-kinase activity, potentiated the expression of MMP-9 induced by both cytokines. In contrast, platelet-derived growth factor (PDGF), an inducer of PI 3-kinase activity in C6 cells, inhibited IL-1- or TNF-alpha-induced MMP-9 secretion. Accordingly, this inhibition by PDGF was prevented by wortmannin. Furthermore, stable C6 clones over-expressing the dominant-negative form the regulatory subunit of PI 3-kinase potentiated the expression of MMP-9 induced by IL-1 or TNF-alpha. Taken together, these results suggest that PI 3-kinase may act as a negative regulator of MMP-9 expression in C6 glioma cells."xsd:string |
| http://purl.uniprot.org/citations/12200127 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(02)02008-9"xsd:string |
| http://purl.uniprot.org/citations/12200127 | http://purl.uniprot.org/core/author | "Esteve P.O."xsd:string |
| http://purl.uniprot.org/citations/12200127 | http://purl.uniprot.org/core/author | "St-Pierre Y."xsd:string |
| http://purl.uniprot.org/citations/12200127 | http://purl.uniprot.org/core/author | "Potworowski E.F."xsd:string |
| http://purl.uniprot.org/citations/12200127 | http://purl.uniprot.org/core/author | "Robledo O."xsd:string |
| http://purl.uniprot.org/citations/12200127 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12200127 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/12200127 | http://purl.uniprot.org/core/pages | "864-869"xsd:string |
| http://purl.uniprot.org/citations/12200127 | http://purl.uniprot.org/core/title | "Induced expression of MMP-9 in C6 glioma cells is inhibited by PDGF via a PI 3-kinase-dependent pathway."xsd:string |
| http://purl.uniprot.org/citations/12200127 | http://purl.uniprot.org/core/volume | "296"xsd:string |
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