| http://purl.uniprot.org/citations/12200381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12200381 | http://www.w3.org/2000/01/rdf-schema#comment | "The long-term immunologic effects of intermittent interleukin 2 (IL-2) therapy were evaluated in a cross-sectional study by comparing 3 groups: HIV-seronegative volunteers, HIV-infected (HIV(+)) patients receiving highly active antiretroviral therapy (HAART), and HIV(+) patients receiving HAART and intermittent IL-2. Whole-blood immunophenotyping was performed to study expression of the IL-2 receptor chains on T lymphocytes and natural killer cells and to further characterize CD4(+)/CD25(+) T cells. Increased CD25 expression, especially in CD4(+) T cells but also in CD8(+) T cells, without increases in expression of the beta and gamma chains of the IL-2 receptor was detected in the IL-2 group. Up to 79% of naive CD4(+) T cells (median, 61%) from patients in the IL-2 group expressed CD25, and the number of naive CD4(+)/CD25(+) T cells correlated positively with both the total and naive CD4(+) T-cell counts. A discrete population of CD45 double intermediate RA(+)/RO(+) CD4(+) cells was also preferentially expanded in the IL-2 group, and the number of these cells strongly correlated with the total CD4(+) count. Despite increases in CD25 expression, T lymphocytes from patients treated with IL-2 did not have increased expression of early (CD69) or late (CD95) activation markers or evidence of recent proliferation (Ki67). Both CD4(+)/CD25(+) and CD4(+)/CD25(-) cells from IL-2-treated HIV(+) patients proliferated in response to mitogens, specific antigens, and T-cell-receptor-mediated stimuli. Thus, intermittent administration of IL-2 in HIV(+) patients leads to preferential expansion of a unique subset of CD4(+) T cells that may represent a critical population in T-cell homeostasis."xsd:string |
| http://purl.uniprot.org/citations/12200381 | http://purl.uniprot.org/core/author | "Kovacs J.A."xsd:string |
| http://purl.uniprot.org/citations/12200381 | http://purl.uniprot.org/core/author | "Hahn B."xsd:string |
| http://purl.uniprot.org/citations/12200381 | http://purl.uniprot.org/core/author | "Sereti I."xsd:string |
| http://purl.uniprot.org/citations/12200381 | http://purl.uniprot.org/core/author | "Lane H.C."xsd:string |
| http://purl.uniprot.org/citations/12200381 | http://purl.uniprot.org/core/author | "Metcalf J.A."xsd:string |
| http://purl.uniprot.org/citations/12200381 | http://purl.uniprot.org/core/author | "Hallahan C.W."xsd:string |
| http://purl.uniprot.org/citations/12200381 | http://purl.uniprot.org/core/author | "Davey R.T."xsd:string |
| http://purl.uniprot.org/citations/12200381 | http://purl.uniprot.org/core/author | "Baseler M.W."xsd:string |
| http://purl.uniprot.org/citations/12200381 | http://purl.uniprot.org/core/author | "Hengel R.L."xsd:string |
| http://purl.uniprot.org/citations/12200381 | http://purl.uniprot.org/core/author | "Martinez-Wilson H."xsd:string |
| http://purl.uniprot.org/citations/12200381 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12200381 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/12200381 | http://purl.uniprot.org/core/pages | "2159-2167"xsd:string |
| http://purl.uniprot.org/citations/12200381 | http://purl.uniprot.org/core/title | "Long-term effects of intermittent interleukin 2 therapy in patients with HIV infection: characterization of a novel subset of CD4(+)/CD25(+) T cells."xsd:string |
| http://purl.uniprot.org/citations/12200381 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/12200381 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12200381 |
| http://purl.uniprot.org/citations/12200381 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12200381 |
| http://purl.uniprot.org/uniprot/#_A2N4P8-mappedCitation-12200381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12200381 |
| http://purl.uniprot.org/uniprot/#_B2R9M9-mappedCitation-12200381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12200381 |
| http://purl.uniprot.org/uniprot/#_O15163-mappedCitation-12200381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12200381 |
| http://purl.uniprot.org/uniprot/#_H0Y5Z0-mappedCitation-12200381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12200381 |
| http://purl.uniprot.org/uniprot/#_Q13169-mappedCitation-12200381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12200381 |
| http://purl.uniprot.org/uniprot/#_Q71V48-mappedCitation-12200381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12200381 |